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221. Gokhale, S., Lu, W., Zhu, S., Liu, Y., Hart, R. P., Rabinowitz, J. D., Xie, P. Elevated choline kinase ?-mediated choline metabolism supports the prolonged survival of TRAF3-deficient B lymphocytes. J. Immunol.. 204:459-471. 2019.
220. Estrella, M. A., Du, J., Chen, L., Rath, S., Prangley, E., Chitrakar, A., Aoki, T., Schedl, P., Rabinowitz, J., Korennykh, A. The metabolites NADP and NADPH are the targets of the circadian protein Nocturnin (Curled). Nature Commun..10:2367. 2019;10:2367
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209. Schober, A. F., Mathis, A. D., Ingle, C., Park, J. O., Chen, L., Rabinowitz, J. D., Junier, I., Rivoire, O., Reynolds, K. A. A Two-Enzyme Adaptive Unit within Bacterial Folate Metabolism. Cell Rep..27:3359-3370.e7. 2019;27:3359-3370.e7
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205. Bradley, P. H., Gibney, P. A., Botstein, D., Troyanskaya, O. G., Rabinowitz, J. D. Minor Isozymes Tailor Yeast Metabolism to Carbon Availability. mSystems, 4(1)pii: e00170-18. 2019.
204. Rodriguez, A. E., Ducker, G. S., Billingham, L. K., Martinez, C. A., Mainolfi, N., Suri, V., Friedman, A., Manfredi, M. G., Weinberg, S. E., Rabinowitz, J. D., Chandel, N. S. Serine Metabolism Supports Macrophage IL-1? Production. Cell Metabolism.29:1003-1011. 2019;29:1003-1011
203. Wang, L., Xing, X., Chen, L., Yang, L., Su, X., Rabitz, H. A., Lu, W., Rabinowitz, J. D. Peak annotation and verification engine (PAVE) for untargeted LC-MS metabolomics. Anal Chem..91:1838-1846. 2019;91:1838-1846
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201. Ron-Harel, N., Notarangelo, G., Ghergurovich, J. M., Paulo, J. A., Sage, P. T., Santos, D., Satterstrom, F. K., Gygi, S. P., Rabinowitz, J. D., Sharpe, A. H., Haigis, M. C. Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice. Proc. Natl. Acad. Sci. USA. 115:13347-13352. 2018.
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196. Hui, S., Rabinowitz, J. D. An unexpected trigger for calorie burning in brown fat. Nature.560:38-39. 2018;560:38-39
195. Guan, D., Xiong, Y., Borck, P. C., Jang, C., Doulias, P. T., Papazyan, R., Fang, B., Jiang, C., Zhang, Y., Briggs, E. R., Hu, W., Steger, D., Ischiropoulos, H., Rabinowitz, J. D., Lazar, M. A. Diet-Induced Circadian Enhancer Remodeling Synchronizes Opposing Hepatic Lipid Metabolic Processes. Cell.174:831-842. 2018;174:831-842
194. Li, S. H., Li, Z., Park, J. O., King, C. G., Rabinowitz, J. D., Wingreen, N. S., Gitai, Z. Escherichia coli translation strategies differ across carbon, nitrogen and phosphorus limitation conditions. Nature Microbiol..3:939-947. 2018;3:939-947
193. Rodan, L. H., Qi, W., Ducker, G. S., Demirbas, D., Laine, R., Yang, E., Walker, M. A., Eichler, F., Rabinowitz, J. D., Anselm, I., Berry, G. T. 5, 10-methenyltetrahydrofolate synthetase deficiency causes a neurometabolic disorder associated with microcephaly, epilepsy, and cerebral hypomyelination. Mol. Genet. Metabolism. 125:118-216. 2018.
192. Tanner, L. B., Goglia, A. G., Wei, M. H., Sehgal, T., Parsons, L. R., Park, J. O., White, E., Toettcher, J. E., Rabinowitz, J. D. Four key steps control glycolytic flux in mammalian cells. Cell Systems.7:49-62. 2018;7:49-62
191. Davila, A., Liu. L., Chellappa, K., Redpath, P., Nakamaru-Ogiso, E., Paolella, L. M., Zhang, Z., Migaud, M. E., Rabinowitz, J. D., Baur, J. A. Nicotinamide adenine dinucleotide is transported into mammalian mitochondria. eLife, 7: e33246. 2018.
190. Nofal, M., Rabinowitz, J. D. Ribosomes on the night shift. Science.360:710-711. 2018;360:710-711
189. Jang, C., Chen, L., Rabinowitz, J. D. Metabolomics and isotope tracing. Cell.173:822-837. 2018;173:822-837
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187. Miller, R. A., Shi, Y., Lu, W., Pirman, D. A., Jatkar, A., Blatnik, M., Wu, H., Cárdenas, C., Wan, M., Foskett, J. K., Park, J. O., Zhang, Y., Holland, W. L., Rabinowitz, J. D., Birnbaum, M. J. Targeting hepatic glutaminase activity to ameliorate hyperglycemia. Nature.24:518-524. 2018;24:518-524
186. Lanaspa, M. A., Andres-Hernando, A., Orlicky, D. J., Cicerchi, C., Jang, C., Li, N., Milagres, T., Kuwabara, M., Wempe, M. F., Rabinowitz, J. D., Johnson, R. J., Tolan, D. R. Ketohexokinase C blockade ameliorates fructose-induced metabolic dysfunction in fructose-sensitive mice. J. Clin. Invest.. 128:2226-2238. 2018.
185. Gibney, P. A., Schieler, A., Chen, J. C., Bacha-Hummel, J. M., Botstein, M., Volpe, M., Silverman, S. J., Xu, Y., Bennett, B. D., Rabinowitz, J. D., Botstein, D. Common and divergent features of galactose-1-phosphate and fructose-1-phosphate toxicity in yeast. Mol. Biol. Cell. 29:897-910. 2018.
184. McKee, S. E., Zhang, S., Chen, L., Rabinowitz, J. D., Reyes, T. M. Perinatal high fat diet and early life methyl donor supplementation alter one carbon metabolism and DNA methylation in the brain. J. Neurochem. 145: 362-373. 2018.
183. Jang, C. J., Hui, S., Lu, W., Cowan, A. J., Morscher, R. J., Lee, G., Liu, W., Tesz, G. J., Birnbaum, M. J., Rabinowitz, J. D. The small intestine converts dietary fructose into glucose and organic acids. Cell Metabolism.27:351-361. 2018;27:351-361
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181. Pavlova, N. N., Hui, S., Ghergurovich, J. M., Fan, J., Intlekofer, A. M., White, R. M., Rabinowitz, J. D., Thompson, C. B., Zhang, J. As extracellular glutamine levels decline, asparagine becomes an essential amino acid. Cell Metabolism.27:428-438. 2018;27:428-438
180. Lin, K. C., Torga, G., Wu, A., Rabinowitz, J. D., Murray, W. J., Sturm, J. C., Pienta, K. J., Austin, R. Epithelial and mesenchymal prostate cancer cell population dynamics on a complex drug landscape. Converg. Sci. Phys. Oncol.. 3:pii: 045001. 2017.
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176. Hui, S., Ghergurovich, J.M., Morscher, R. J., Jang, C., Teng, X., Lu, W., Esparza, L. A., Reya, T., Le, Z., Yanxiang Guo, J., White, E., Rabinowitz, J. D. Glucose feeds the TCA cycle via circulating lactate. Nature.551:115-118. 2017;551:115-118
175. Wooldridge, A. L., Bischof, R. J., Liu, H., Heinemann, G. K., Hunter, D. S., Giles, L. C., Simmons, R. A., Lien, Y. C., Rabinowitz, J. D., Kind, K. L., Owens, J. A., Clifton, V. L., Gatford, J. L. Late gestation maternal dietary methyl donor and cofactor supplementation in sheep partially reverses protection against allergic sensitization by IUGR. Am. J. Physiol. Regul. Integr. Comp. Physiol.. 314:R22-R33. 2018.
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173. Kim, H. I., Raffler, J., Lu, W., Lee, J. J., Abbey, D., Saleheen, D., Rabinowitz, J. D., Bennett, M. J., Hand, N. J., Brown, C., Rader, D. J. Fine mapping and functional analysis reveal a role of SLC22A1 in acylcarnitine transport. Am. J. Hum. Genet.. 101:489-502. 2017.
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171. Zhang, Z., Chen, L., Liu, L., Su, X., Rabinowitz, J. D. Chemical basis for deuterium labeling of fat and NADPH. J. Am. Chem. Soc.. 139:14368-14371. 2017.
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168. Oslund, R. C., Su, X., Haugbro, M., Kee, J. M., Esposito, M., David, Y., Wang, B., Ge, E., Perlman, D. H., Kang, Y., Muir, T. W., Rabinowitz, J. D. Bisphosphoglycerate mutase controls serine pathway flux via 3-phosphoglycerate. Nature Chem. Biol.. 13:1081-1087. 2017.
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165. Rajeshkumar, N. V., Yabuuchi, S., Pai, S., De Oliveira, E., Kamphorst, J. J., Rabinowitz, J. D., Tejero, H., Al-Shahrour, F., Hidalgo, M., Maitra, A., Dang, C. V. Treatment of pancreatic cancer patient-derived xenograft panel with metabolic inhibitors reveals efficacy of phenformin. Clin. Cancer Res.. 23:5639-5647. 2017.
164. Gong, Y., Cao, R., Ding, G., Hong, S., Zhou, W., Lu, W., Damle, M., Fang, B., Wang, C. C., Qian, J., Lie, N., Lanzillotta, C., Rabinowitz, J. D., Sun, Z. Integrated omics approaches to characterize a nuclear receptor corepressor-associated histone deacetylase in mouse skeletal muscle. Mol. Cell Endocrinol.. 471:22-32. 2017.
163. Choi, J., Rajagopal, A., Xu, Y. F., Rabinowitz, J. D., O'Shea, E. K. A systematic genetic screen for genes involved in sensing inorganic phosphate availability in Saccharomyces cerevisiae. PLoS One.12:e0176085. 2017;12:e0176085
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154. Guo, J. Y., Teng, X., Laddha, S. V., Ma, S., Van Nostrand, S. C., Yang, Y., Khor, S., Chan, C. S., Rabinowitz, J. D., White, E. Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells. Genes Dev..30:1704-17. 2016;30:1704-17
153. Frederick, D. W., Loro, E., Liu, L., Davila, A. Jr., Chellappa, K., Silverman, I. M., Quinn, W. J. 3rd, Gosai, S. J., Tichy, E. D., Davis, J. G., Mourkioti, F., Gregory, B. D., Dellinger, R. W., Redpath, P., Migaud, M. E., Nakamaru-Ogiso, E., Rabinowitz, J. D., Khurana, T. S., Baur, J. A. Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle. Cell Metabolism.24:269-82. 2016;24:269-82
152. Ron-Harel, N., Santos, D., Ghergurovich, J. M., sage, P. T., Reddy, A., Lovitch, S. B., Dephoure, N., Satterstrom, F. K., Sheffer, M., Spinelli, J. B., Gygi, S., Rabinowitz, J. D., Sharpe, A. H., Haigis, M. C. Mitochondrial biogenesis and proteome remodeling promote one-carbon metabolism for T cell activation. Cell Metabolism.24:104-17. 2016;24:104-17
151. Teng, X., Emmett M. J., Lazar, M. A., Goldberg, E., Rabinowitz, J. D. Lactate dehydrogenase C produces S-2-Hydroxyglutarate in mouse testis. ACS Chem. Biol.. 11:2420-7. 2016.
150. Titchenell, P. M., Quinn, W. J., Lu, M., Chu, Q., Lu, W., Li, C., Chen, H., Monks, B. R., Chen, J., Rabinowitz, J. D., Birnbaum, M. J. Direct hepatocyte insulin signaling is required for lipogenesis but is dispensable for the suppression of glucose production. Cell Metabolism.23:1154-66. 2016;23:1154-66
149. Ducker, G. S., Chen, L., Morscher, R. J., Ghergurovich, J. M., Esposito, M., Teng, X., Kang, Y., Rabinowitz, J. D. Reversal of cytosolic one-carbon flux compensates for loss of the mitochondrial folate pathway. Cell Metabolism.23:1140-53. 2016;23:1140-53
148. Park, J. O., Rubin, S. A., Xu, Y. F., Amador-Noguez, D., Fan, J., Shlomi, T., Rabinowitz, J. D. Metabolite concentrations, fluxes and free energies imply efficient enzyme usage. Nature Chem. Biol.. 12:482-9. 2016.
147. Bren, A., Park, J. O., Towbin, B. D., Dekel, E., Rabinowitz, J. D., Alon, U. Glucose becomes one of the worst carbon sources for E.coli on poor nitrogen sources due to suboptimal levels of cAMP. Sci. Rep.. 6:24834. 2016.
146. Rabinowitz, J. D., Coller, H. A. Partners in the Warburg effect. Elife.5:e15938. 2016;5:e15938
145. Liu, L., Shah, S., Fan, J., Park, J. O., Wellen, K. E., Rabinowitz, J. D. Malic enzyme tracers reveal hypoxia-induced switch in adipocyte NADPH pathway usage. Nature. Chem. Biol.. 12:345-52. 2016.
144. Koivunen, P., Fell, S. M., Lu, W., Rabinowitz, J. D., Kung, A. L., Schlisio, S. The 2-oxoglutarate analog 3-oxoglutarate decreases normoxic hypoxia-inducible factor 1? in cancer cells, induces cell death, and reduces tumor xenograft growth. Hypoxia.4:15-27. 2016;4:15-27
143. Jang, C., Oh, S. F., Wada, S., Rowe, G. C., Liu, L., Chan, M. C., Rhee, J., Hoshino, A., Kim, B., Ibrahim, A., Baca, L.G., Kim, E., Ghosh, C. C., Parikh, S. M., Jiang, A., Chu, Q., Forman, D. E., Lecker, S. H., Krishnaiah, S., Rabinowitz, J. D., Weljie, A. M., Baur, J. A., Kasper, D. L., Arany, Z. A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance. Nature Medicine.22:421-6. 2016;22:421-6
142. Zong, W. X., Rabinowitz, J. D., White, E. Mitochondria and cancer. Mol. Cell. 61:667-76. 2016.
141. Su, X., Wellen, K. E., Rabinowitz, J. D. Metabolic control of methylation and acetylation. Curr. Opin. Chem. Biol.. 30:52-60. 2016.
140. Bott, A. J., Peng, I. C., Fan, Y., Faubert, B., Zhao, L., Li, J., Neidler, S., Sun, Y., Jaber, N., Krokowski, D., Lu, W., Pan, J. A., Powers, S., Rabinowitz, J., Hatzoglou, M., Murphy, D. J., Jones, R., Wu, S., Girnun, G., Zong, W. X. Oncogenic Myc induces expression of glutamine synthetase through promoter demethylation. Cell Metabolism 22: 1068-77. 2015.
139. Mok, W. W., Park, J. O., Rabinowitz, J. D., Brynildsen, M. P. RNA futile cycling in model persisters derived from MazF accumulation. mBio, 6: e01588-15. 2015.
138. Rajeshkumar, N. V., Dutta, P., Yabuuchi, S., de Wilde, R. F., Matrinez, G. V., Le, A., Kamphorst, J. J., Rabinowitz, J. D., Jain, S. K., Hidalgo, M., Dang, C. V., Gillies, R. J., Maitra, A. Therapeutic targeting of the Warburg effect in pancreatic cancer relies on an absence of p53 function. Cancer Res..75:3355-64. 2015;75:3355-64
137. Gibney, P. A., Schieler, A., Chen, J. C., Rabinowitz, J. D., Botstein, D. Characterizing the in vivo role of trehalose in Saccharomyces cerevisiae using the AGT1 transporter. Proc. Natl. Acad. Sci. USA. 112:6116-21. 2015.
136. Purdy, J. G., Shenk, T., Rabinowitz, J. D. Fatty Acid elongase 7 catalyzes lipidome remodeling essential for human cytomegalovirus replication. Cell Rep..10:1375-85. 2015;10:1375-85
135. Buescher, J. M., et. al. A roadmap for interpreting 13C metabolite labeling patterns from cells. Curr. Opin. Biotechnol., 34C: 189-201. 2015.
134. Kamphorst, J. J., Nofal, M., Commisso, C., Hackett, S. R., Lu, W., Grabocka, E., Vander Heiden, M. G., Miller, G., Drebin, J. A., Bar-Sagi, D., Thompson, C. B., Rabinowitz, J. D. Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein. Cancer Res..75:544-53. 2015;75:544-53
133. Ducker, G. S., Rabinowitz, J. D. ZMP: A master regulator of one-carbon metabolism. Mol. Cell. 57:203-4. 2015.
132. Xu, Y. F., Lu, W., Rabinowitz, J. D. Avoiding misannotation of in-source fragmentation products as cellular metabolites in liquid chromatography-mass spectrometry-based metabolomics. Anal. Chem.. 87:2273-81. 2015.
131. Aristilde, L., Lewis, I. A., Park, J. O., Rabinowitz, J. D. Hierarchy in pentose sugar metabolism in clostridium acetobutylicum. Appl. Environ. Microbiol.. 81:1452-62. 2014.
130. Hwang, J., Purdy, J. G., Wu, K., Rabinowitz, J. D., Shenk, T. Estrogen-related receptor ? is required for efficient human cytomegalovirus replication. Proc. Natl. Acad. Sci. USA. 111:E5706-15. 2014.
129. Kamphorst, J. J., Chung, M. K., Fan, J., Rabinowitz, J. D. Quantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate. Cancer Metabolism.2:23. 2014;2:23
128. Fan, J., Teng, X., Liu, L., Mattaini, K. R., Looper, R. E., Vander Heiden, M. G., Rabinowitz, J. D. Human phosphoglycerate dehydrogenase produces the oncometabolite d-2-hydroxyglutarate. ACS Chem. Biol.. 10:510-6. 2014.
127. Castellana, M., Wilson, M. Z., Xu, Y., Joshi, P., Cristea, I. M., Rabinowitz, J. D., Gitai, Z., Wingreen, N. S. Enzyme clustering accelerates processing of intermediates through metabolic channeling. Nature Biotechnology.32:1011-8. 2014;32:1011-8
126. Stincone, A., Prigione, A., Cramer, T., Wamelink, M. M., Campbell, K., Cheung, E., Olin-Sandoval, V., Gruening, N. M., Krueger, A., Tauqeer Alam, M., Keller, M. A., Breitenbach, M., Brindle, K. M., Rabinowitz, J. D., Raiser, M. The return of metabolism: biochemistry and physiology of the pentose phosphate pathway. Biol. Rev. Camb. Philos. Soc.. 90:927-63. 2014.
125. Zhang, J., Fan, J., Venneti, S., Cross, J. R., Takagi, T., Bhinder, B., Djaballah, H., Kanai, M., Cheng, E. H., Judkins, A. R., Pawel, B., Baggs, J., Cherry, S., Rabinowitz, J. D., Thompson, C. B. Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion. Mol. Cell. 56:205-18. 2014.
124. Ye, J., Fan, J. Venneti, S., Wan, Y. W., Pawel, B. R., Zhang, J., Finley, L. W., Lu, C., Lindsten, T., Cross, J., Qing, G., Liu, Z., Simon, M. C., Rabinowitz, J.D., Thompson, C. Serine catabolism regulates mitochondrial redox control during hypoxia. Cancer Discov..4:1406-17. 2014;4:1406-17
123. Mathew, R., Khor, S., Hackett, S. R., Rabinowitz, J. D., Perlman, D. H., White, E. Functional role of autophagy-mediated proteome remodeling in cell survival signaling and innate immunity. Mol. Cell. 55:916-30. 2014.
122. Karsli-Uzunbas, G., Guo, J. Y., Price, S., Teng, X., Laddha, S. V., Khor, S. Kalaany, N. Y., Jacks, T., Chan, C. S., Rabinowitz, J. D., White, E. Autophagy is required for glucose homeostasis and lung tumor maintenance. Cancer Discov..4:914-27. 2014;4:914-27
121. Fan, J., Ye, J., Kamphorst, J. J., Shlomi, T., Thompson, C. B., Rabinowitz, J. D. Quantitative flux analysis reveals folate-dependent NADPH production. Nature.510:298-302. 2014;510:298-302
120. Breunig, J. S., Hackett, S. R., Rabinowitz, J. D., Kruglyak, L. Genetic basis of Metabolome variation in yeast. PLoS Genet..10:e1004142. 2014;10:e1004142
119. Shlomi, T., Fan, J., Tang, B., Kruger, W. D., Rabinowitz, J. D. Quantitation of cellular metabolic fluxes of methionine. Anal. Chem.. 86:1583-91. 2014.
118. Kliegman, J. I., Fiedler, D., Ryan, C. J., Xu, Y. F., Su, X. Y., Thomas, D., Caccese, M. C., Cheng, A., Shales, M., Rabinowitz, J. D., Krogan, N. J., Shokat, K. M. Chemical genetics of rapamycin-insensitive TORC2 in S. cerevisiae. Cell Rep..5:1725-36. 2013;5:1725-36
117. Fan, J., Kamphorst, J. J., Mathew, R., Chung, M. K., White, E., Shlomi, T., Rabinowitz, J. D. Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia. Mol. Syst. Biol.. 9:712. 2013.
116. Grady, S. L., Purdy, J. G., Rabinowitz, J. D., Shenk, T. Argininosuccinate synthetase 1 depletion produces a metabolic state conducive to herpes simplex virus 1 infection. Proc. Natl. Acad. Sci. USA. 110:E5006-15. 2013.
115. Tchigvintsev, A., Tchigvintsev, D., Flick, R., Popovic, A., Dong, A., Xu, X., Brown, G., Lu, W., Wu, H., Cui, H., Dombrowski, L., Joo, J. C., Beloglazova, N., Min, J., Savchenko, A., Caudy, A. A., Rabinowitz, J. D., Murzin, A. G., Yakunin, A. F. Biochemical and structural studies of conserved maf proteins revealed nucleotide pyrophosphatases with a preference for modified nucleotides. Chem. Biol.. 20:1386-1398. 2013.
114. Tepper, N., Noor, E., Amador-Noguez, D., Haraldsdóttir, H. S., Milo, R., Rabinowitz, J., Liebermeister, W., Shlomi, T. Steady-state metabolite concentrations reflect a balance between maximizing enzyme efficiency and minimizing total metabolite load. PLoS One.8:e75370. 2013;8:e75370
113. Fan J., Kamphorst, J. J., Rabinowitz, J. D., Shlomi, T. Fatty acid labeling from glutamine in hypoxia can be explained by isotope exchange without net reductive IDH flux. J. Biol. Chem.. 288:31363-31369. 2013.
112. Rabinowitz, J. D. and Silhavy, T. J. Systems biology: metabolite turns master regulator. Nature.500:283-284. 2013;500:283-284
111. Reaves, M. L., Young, B. D., Hosios, A. M., Xu, Y. F., Rabinowitz, J. D. Pyrimidine homeostasis is accomplished by directed overflow metabolism. Nature.500:237-241. 2013;500:237-241
110. Guo, L. Y., Karsli-Uzungas, G., Mathew, R., Aisner, S. C., Kamphorst, J. J., Strohecker, A. M., Chen, G., Price, S., Lu, W., Teng, X., Snyder, E., Santanam, U., Dipaola, R. S., Jacks, T., Rabinowitz, J. D., White, E. Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis. Genes Dev..27:1447-1461. 2013;27:1447-1461
109. Koyuncu, E., Purdy, J. G., Rabinowitz, J. D., Shenk, T. Saturated very long fatty acids are required for the production of infectious human cytomegalovirus progeny. PLoS Pathog..9:e1003333. 2013;9:e1003333
108. Kamphorst, J. J., Cross, J. R., Fan., J., de Stanchina, E., Mathew, R., White, E. P., Thompson, C. B., Rabinowitz, J. D. Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids. Proc. Natl. Acad. Sci. USA. 110:8882-8887. 2013.
107. Xu, Y.F., Létisse, F., Absalan, F., Lu, W., Kuznetsova, E., Brown, G., Caudy, A. A., Yakunin, A. F., Broach, J. R., Rabinowitz, J. D. Nucleotide degradation and ribose salvage in yeast. Mol. Syst. Biol.. 9:665. 2013.
106. Commiso, C., Davidson, S. M., Soydaner-Azeloglu, R. G., Parker, S. J., Kamphorst, J. J., Hackett, S., Grabocka, E., Nofal, M., Drebin, J. A., Thompson, C.B., Rabinowitz, J. D., Metallo, C. M. Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells. Nature.497:633-637. 2013;497:633-637
105. Shlomi, T. and Rabinowitz, J. D. Metabolism: Cancer mistunes methylation. Nat. Chem. Biol.. 9:293-4. 2013.
104. Xu, Y. F., Zhao,X., Glass, D. S., Absalan, F., Perlman, D. H., Broach, J. R., Rabinowitz, J. D. Regulation of yeast pyruvate kinase by ultrasensitive allostery independent of phosphorylation. Mol. Cell. 48:52-62. 2012.
103. Bray, K., Mathew, R., Lau, A., Kamphorst, J. J., Fan, J., Chen, J., Chen, H. Y., Ghavami, A., Stein, M., Dipaola, R. S., Zhang, D., Rabinowitz, J. D., White, E. Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition. PLoS One.7:e41831. 2012;7:e41831
102. Reaves, M. L., Sinha, S., Rabinowitz, J. D., Kruglyak, L., Redfield, R. J. Absence of detectable arsenate in DNA from arsenate-grown GFAJ-1 cells. Science.337:470-474. 2012;337:470-474
101. Grady, S. L., Hwang, J., Vastag, L., Rabinowitz, J. D., Shenk, T. Herpes simplex virus type 1 infection activates poly (ADP-ribose) polymerase and triggers the degradation of poly (ADP-ribose) glycohydrolase. J. Virol.. 86:8259-8268. 2012.
100. Rabinowitz, J. D. and Vastag, L. Teaching the design principles of metabolism. Nature Chem. Biol.. 8:497-501. 2012.
99. Xu., Y., Amador-Noguez, D., Reaves, M. L., Feng, X. J., Rabinowitz, J. D. Ultrasensitive regulation of anapleurosis via allosteric activation of PEP carboxylase. Nature Chem. Biol.. 8:562-568. 2012.
98. Ye, J., Mancuso, A., Tong, X., Ward, P. S., Fan, J., Rabinowitz, J. D., Thompson, C. B. Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation. Proc. Natl. Acad. Sci. USA. 109:6904-6909. 2012.
97. Peterson, C. N., Levchenko, I., Rabinowitz, J. D., Baker, T. A., Silhavy, T. J. RpoS proteolysis is controlled directly by ATP levels in Escherichia coli. Genes Dev..26:548-553. 2012;26:548-553
96. Clasquin, M. F., Melamud, E., Rabinowitz, J. D. LC-MS data processing with MAVEN: A metabolomic analysis and visualization engine. Curr. Protoc. Bioinformatics, Chapter 14: Unit 14.11. 2012.
95. Terry, L. J., Vastag, L., Rabinowitz, J. D., Shenk, T. Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection. Proc. Natl. Acad. Sci. USA. 109:3071-3076. 2012.
94. Rabinowitz, J. D., Purdy, J. G., Vastag, L., Shenk, T., Koyuncu, E. Metabolomics in drug target discovery. Cold Spring Harb. Symp. Quant. Biol.. 76:235-246. 2011.
93. Kamphorst, J. J., Fan, J., Lu, W., White, E., Rabinowitz, J. D. Liquid chromatography-high resolution mass spectrometry analysis of fatty acid metabolism. Anal. Chem.. 83:9114-9122. 2011.
92. Doucette, C. D., Schwab, D. J., Wingreen, N. S., Rabinowitz, J. D. ?-Ketoglutarate coordinates carbon and nitrogen utilization via enzyme I inhibition. Nature Chem. Biol.. 7:894-901. 2011.
91. Amador-Noguez, D., Brasg, I. A., Feng, X. J., Roquet, N., Rabinowitz, J. D. Metabolome remodeling during the acidogenic-solventogenic transition in Clostridium acetobutylicum. Appl. Environ. Microbiol.. 77:7984-7997. 2011.
90. Strelko, J. L., Lu, W., Dufort, F. J., Seyfried, T. N., Chiles, T. C., Rabinowitz, J. D., Roberts, M. F. Itaconic acid is a mammalian metabolite induced during macrophage activation. J. Am. Chem. Soc.. 133:16386-16389. 2011.
89. Vastag, L., Koyuncu, E., Grady, S. L., Shenk, T. E., Rabinowitz, J. D. Divergent effects of human cytomegalovirus and herpes simplex virus-1 on cellular metabolism. PLoS Pathog..7:e1002124. 2011;7:e1002124
88. Liu, S. T. H., Sharon-Frilling, R., Ivanova, P., Milne, S. B., Myers, D. S., Rabinowitz, J. D., Brown, H. A., Shenk, T. Synaptic vesicle-like lipidome of human cytomegalovirus virions reveals a role for SNARE machinery in virion egress. Proc. Natl. Acad. Sci. USA. 108:12869-12874. 2011.
87. Petti, A. A., Crutchfield, C. A., Rabinowitz, J. D., Botstein, D. Survival of starving yeast is correlated with oxidative stress response and nonrespiratory mitochondrial function. Proc. Natl. Acad. Sci. USA. 108:E1089-98. 2011.
86. Clasquin, M. F., Melamud, E., Singer, A., Gooding, J. R., Xu, X., Dong, A., Cui, H., Campagna, S. R., Savchenko, A., Yakunin, A. F., Rabinowitz, J. D., Caudy, A. A. Riboneogenesis in yeast. Cell.145:969-980. 2011;145:969-980
85. Reaves, M. L. and Rabinowitz, J. D. Characteristic phenotypes associated with ptsN-null mutants in Escherichia coli K-12 are absent in strains with functional ilvG. J. Bacteriol.. 193:4576-4581. 2011.
84. Guo, J. X., Chen, H. Y., Mathew, R., Fan, J., Strohecker, A. M., Karsli-Uzunbas, G., Kamphorst, J. J., Chen, G., Lemmons, J. M. S., Karantza, V., Coller, H. A., DiPaola, R. S., Gelinase, C., Rabinowitz, J. D., White, E. Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev..25:460-470. 2011;25:460-470
83. Klosinska, M. M., Crutchfield, C., Bradley, P. J., Broach, J. R. Yeast cells can access distinct quiescent states. Genes Dev..25:336-349. 2011;25:336-349
82. Vastag, L., Jorgensen, P., Peshkin, L., Rabinowitz, J. D., Kirschner, M. W. Remodeling of the metabolome during early frog development. PLoS One.6:e16881. 2011;6:e16881
81. Hart, Y., Madar, D., Yuan, J., Bren, A., Mayo, A. E., Rabinowitz, J. D., Alon, U. Robust control of nitrogen assimilation by a bifunctional enzyme in E. coli. Mol. Cell. 41:117-127. 2011.
80. Merritt, J. H., Ha, D.G., Cowles, K. N., Lu, W., Morales, D. K., Rabinowitz, J., Gitai, Z., O'Toole, G. A. Specific control of Pseudomonas aeruginosa surface-associated behaviors by two c-di-GMP diguanylate cyclases. mBio, 1: e00183-10. 2010.
79. Wellen, K. E., Lu, C., Mancuso, A., Lemons, J. M., Ryczko, M., Dennis, J. W., Rabinowitz, J. D., Coller, H. A., Thompson, C. B. The hexosamine biosynthetic pathway couples growth factor -induced glutamine uptake to glucose metabolism. Genes Dev..24:2784-2799. 2010;24:2784-2799
78. Rabinowitz, J. D. and White, E. Autophagy and metabolism. Science.330:1344-1348. 2010;330:1344-1348
77. Melamud, E., Vastag, L., Rabinowitz, J. D. Metabolomic analysis and visualization engine for LC-MS data. Anal. Chem.. 82:9818-9826. 2010.
76. Seltzer, M. J., Bennett, B. D., Joshi, A. D., Gao, P., Thomas, A. G., Ferraris, D. V., Tsukamoto, T., Rojas, C. J., Slusher, B. S., Rabinowitz, J. D., Dang, C. V., Riggins, G. L. Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1. Cancer Res..70:8981-8987. 2010;70:8981-8987
75. Reaves, M. L., Rabinowitz, J. D. Metabolomics in systems microbiology. Curr. Op. Biotechnol.. 22:17-25. 2010.
74. Lemons, J. M. S., Fenh, X. J., Bennett, B. D., Legesse-Miller, A., Johnson, E. L., Raitman, I., Pollina, E. A., Rabitz, H. A., Rabinowitz, J. D., Coller, H. A. Quiescent fibroblasts exhibit high metabolic activity. PLoS Biol..8:e1000514. 2010;8:e1000514
73. Vander Heiden, M. G., Locasale, J. W., Swanson, K. D., Sharfi, H., Heffron, G.J., Amador-Noguez, D., Christofk, H. R., Wagner, G., Rabinowitz, J. D., Asara, J. M., Cantley, L. C. Evidence for an alternative glycolytic pathway in rapidly proliferating cells. Science.329:1492-1499. 2010;329:1492-1499
72. Amador-Noguez, D., Feng, X. F., Fan, J., Roquet, N., Rabitz, H., Rabinowitz, J. D. Systems-level metabolic flux profiling elucidates a complete, bifurcated tricarboxylic acid cycle in Clostridium acetobutylicum. J. Bacteriol.. 192:4452-4461. 2010.
71. Kwon., Y. K., Higgins, M. B., Rabinowitz, J. D. Antifolate-induced depletion of intracellular glycine and purines inhibits thymineless death in E. coli. ACS Chem. Biol.. 5:787-795. 2010.
70. Goyal, S., Yuan, J., Chen, T., Rabinowitz, J. D., Wingreen, N. S. Achieving optimal growth through product feedback inhibition in metabolism. PLoS Comp. Biol.. 6:e1000802. 2010.
69. Goodarzi, H., Bennett, B. D., Amini, S., Reaves, M. L., Hottes, A. K., Rabinowitz, J. D., Tavazoie, S. Regulatory and metabolic rewiring during laboratory evolution of ethanaol tolerance in E. coli. Mol. Syst. Biol.. 6:378. 2010.
68. Crutchfield, C., Lu, W., Melamud, E., Rabinowitz, J. D. "Mass Spectrometry-Based Metabolomics of Yeast," Methods in Enzymology Guide to Yeast Genetics: Functional Genomics, Proteomics, and Other Systems Analysis. Eds. Weissman, J., Guthrie, C., Fink, G. R. 2nd ed., Vol. 470. San Diego, CA: Elsevier. 393-426. 2010.
67. Kuchma, S. L., Ballok, A. E., Merritt, J. H., Lu, W., Rabinowitz, J. D., O'Toole, G. A. Cyclic-di-GMP-mediated repression of swarming motility by Pseudomonas aeruginosa: The pilY1 gene and and its impact on surface-associated behaviors. J. Bacteriol.. 192:2950-2964. 2010.
66. Lu, W., Clasquin, M. F., Melamud, E., Amador-Noguez, D., Caudy, A. A., Rabinowitz, J. D. Metabolomic analysis via reversed-phase ion-pairing liquid chromatography coupled to a stand alone orbitrap mass spectrometer. Anal. Chem.. 82:3212-3221. 2010.
65. Monds, R. D., Newell, P. D., Wagner, J. C., Schwartzman, J. A., Lu, W., Rabinowitz, J. D. O'Toole, G. A. Di-adenosine tetraphosphate (Ap4A) metabolism impacts biofilm formation by Pseudomonas fluorescens via modulation of c-di-GMP-dependent pathways. J. Bacteriol.. 192:3011-3023. 2010.
64. Ward, P. S., Patel, J., Wise, D. R., Abdel-Wahab, O., Bennett, B. D., Coller, H. A., Cross, J. R., Fantin, V. R., Hedvat, C. V., Perl, A. E., Rabinowitz, J. D., Carroll, M., Su, S. M., Sharp K. A., Levine, R. L., Thompson, C. B. The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Cancer Cell.17:225-234. 2010;17:225-234
63. Lu, X., Bennett, B., Mu, E., Rabinowitz, J., Kang, Y. Metabolomic changes accompanying transformation and acquisition of metastatic potential in a syngeneic mouse mammary tumor model. J. Biol. Chem.. 285:9317-9321. 2010.
62. DiMaggio, P. A., McAllister, S. R., Floudas, C. A., Feng, X. J., Rabinowitz, J. D., Rabitz, H. A. A network flow model for biclustering via optimal re-ordering of data matrices. J. Glob. Optim.. 47:343-354. 2010.
61. DiMaggio, P. A., McAllister, S. R., Floudas, C. A., Feng, X. J., Li, G., Rabinowitz, J. D., Rabitz, H.A. Enhancing molecular discovery using descriptor-free rearrangement clustering techniques for sparse data sets. AIChE J..56:405-418. 2010;56:405-418
60. Boer, V. M., Crutchfield, C. A., Bradley, P. H., Botstein, D., Rabinowitz, J. D. Growth-limiting intracellular metabolites in yeast growing under diverse nutrient limitations. Mol. Biol. Cell. 21:198-211. 2010.
59. Dang, L., White, D. W., Gross, S., Bennett, B. D., Bittinger, M. A., Driggers, E. M., Fanti V. R., Jang, H. G., Jin, S., Keenan, M. C., Marks, M., Prins, R. M., Ward, P. S., Yen, K. E., Liau, L. M., Rabinowitz, J. D., Cantley, L. C., Thompson, C. B., Vander Heiden, M. G., Su S. M. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature.462:739-744. 2009;462:739-744
58. Kelly, R. C., Bolitho, M. E., Higgins, D. A., Lu, W., Ng, W. L., Jeffrey, P. D., Rabinowitz, J. D., Semmelhack, M. F., Hughson, F. M., Bassler, B. L. The Vibrio cholera quorum-sensing autoinducer CAI-1: analysis of the biosynthetic enzyme CqsA. Nat. Chem. Biol.. 5:891-895. 2009.
57. Yuan, J., Doucette, C., Fowler, W. U., Feng, X. J., Piazza, M., Rabitz, H. A., Wingreen, N. S., Rabinowitz, J. D. Metabolomics-driven quantitative analysis of ammonia assimilation in E. coli. Mol. Syst. Biol.. 5:302. 2009.
56. Bennett, B. D., Kimball, E. H., Gao, M., Osterhout, R., Van Dien, S. J., Rabinowitz, J. D. Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli. Nature Chem. Biol.. 5:593-599. 2009.
55. Olszewski, K. L., Morrisey, J. M., Wilinski, D., Burns, J. M., Vaidya, A. B., Rabinowitz, J. D., Llinás, M. Host parasite interactions revealed by Plasmodium falciparum metabolomics. Cell Host Microbe.5:191-199. 2009;5:191-199
54. Shinar, G., Rabinowitz, J. D., Alon, U. Robustness in glyoxylate bypass regulation. PLoS Comp. Biol.. 5:e1000297. 2009.
53. Bradley, P. H., Brauer, M. J., Rabinowitz, J. D., Troyanskaya, O. Coordinated concentration changes of transcript and metabolites in Saccharomyces cerevisiae. PLoS Comp. Biol.. 5:e1000270. 2009.
52. DiMaggio, P. A., McAllister, S. R., Floudas, C. A., Feng, X. J., Rabinowitz, J. D., Rabitz, H. A. Biclustering via optimal re-ordering of data matrices in systems biology: rigorous methods and comparative studies. BMC Bioinformatics.9:458. 2008;9:458
51. McAllister, S. R., Feng, X. J., Dimaggio, P. A. Jr., Floudas, C. A., Rabinowitz, J. D., Rabitz, H. Descriptor-free molecular discovery in large libraries by adaptive substituent reordering. Bioorg. Med. Chem. Lett.. 18:5967-5970. 2008.
50. Munger, J., Bennett, B. D., Parikh, A., Feng, X. J., McArdle, J., Rabitz, H. A., Shenk, T., Rabinowitz, J. D. Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for anti-viral therapy. Nature Biotechnology.26:1179-1186. 2008;26:1179-1186
49. Kwon, Y. K., Lu, W., Melamud, E., Khanam, N., Bognar, A., Rabinowitz, J. D. A domino effect in antifolate drug action in Escherichia coli. Nature Chem. Biol.. 4:602-608. 2008.
48. Yuan, J., Bennett, B. D., Rabinowitz, J. D. Kinetic flux profiling for quantitation of cellular metabolic fluxes. Nature Protocols.3:1328-1340. 2008;3:1328-1340
47. Bennett, B. D., Yuan, J., Kimball, E. H., Rabinowitz, J. D. Absolute quantitation of intracellular metabolite concentrations by an isotope ratio-based approach. Nature Protocols.3:1299-1311. 2008;3:1299-1311
46. Lu, W., Bennett, B. D., Rabinowitz, J. D. Analytical strategies for LC-MS-based targeted metabolomics. J. Chrom. B.. 871:236-242. 2008.
45. Waters, C. M., Lu, W., Rabinowitz, J. D., Bassler, B. L. Quorum sensing controls biofilm formation in Vibrio cholerae through modulation of cyclic di-GMP levels and repression of vpsT. J. Bacteriol.. 190:2527-2536. 2008.
44. Rabinowitz, J. D., Hsiao, J. J., Gryncel, K. R., Kantrowitz, E. R., Feng, X. J., Li, G., Rabitz, H. Dissecting enzyme regulation by multiple allosteric effectors: Nucleotide regulation of aspartate transcarbamoylase. Biochemistry.47:5881-5888. 2008;47:5881-5888
43. Piazza, M., Feng, X. J., Rabinowitz, J. D., Rabitz, H. Diverse metabolic model parameters generate similar methionine cycle dynamics. J. Theor. Biol.. 251:628-639. 2008.
42. Cui, H., Hayashi, A., Sun, H. S., Belmares, M. P., Cobey, C., Phan, T., Schweizer, J., Salter, M. W., Wang, Y. T., Tasker, R. A., Garman, D., Rabinowitz, J., Lu, P. S., Tymianski, M. PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors. J. Neurosci.. 27:9901-9915. 2007.
41. Xavier, K. B., Miller, S. T., Lu, W., Kim, J. H., Rabinowitz, J., Pelczer, I., Semmelhack, M. F., Bassler, B. L. Phosphorylation and processing of the quorum-sensing molecule AI-2 in enteric bacteria. ACS Chem. Biol.. 2:128-136. 2007.
40. Yuan, J., Rabinowitz, J. D. Differentiating metabolites formed from de novo synthesis versus macromolecule decomposition. J. Am. Chem. Soc.. 129:9294-9295. 2007.
39. Rabinowitz, J. D., Kimball, E. Acidic acetonitrile for cellular metabolome extraction from Escherichia coli. Anal. Chem.. 79:6167-6173. 2007.
38. Lu, W., Kwon, Y. K., Rabinowitz, J.D. Isotope ratio-based profiling of microbial folates. J. Am. Soc. Mass Spectr.. 18:898-909. 2007.
37. Campagna, S. R., Rabinowitz, J. D. Metabolome quantitation mass spectrometry. G.I.T. Laboratory J., 7-8: 26-27. 2007.
36. Rabinowitz, J. D. Cellular metabolomics of Escherichia coli. Exp. Rev. Proteomics. 4:187-198. 2007.
35. Avram, M. J., Henthorn, T. K., Spyker, D. A., Krejcie, T. C., Lloyd, P. M., Cassella, J. V., Rabinowitz, J. D. Recirculatory pharmacokinetic model of the uptake, distribution, and bioavailability of prochlorperazine administered as a thermally generated aerosol in a single breath to dogs. Drug Metabolism Dispos..35:262-267. 2007;35:262-267
34. Bao, Q., Lu, W., Rabinowitz, J. D., Shi, Y. Calcium blocks formation of apoptosome by preventing nucleotide exchange in Apaf-1. Mol. Cell. 25:181-192. 2007.
33. Myers, D. J., Timmons, R. D., Lu, A. T., Hale, R. L., Solas, D. W., Soni, P., Rabinowitz, J. D. Effect of film thickness on thermal aerosol generation. Pharm. Res.. 24:336-342. 2007.
32. Brauer, M. J., Yuan, J., Bennett, B. D., Lu, W., Kimball, E., Botstein, D., Rabinowitz, J. D. Conservation of the metabolomic response to starvation across two divergent microbes. Proc. Natl. Acad. Sci. USA. 103:19302-19307. 2006.
31. Munger, J., Bajad, S. U., Coller, H. A., Shenk, T., Rabinowitz, J. D. Dynamics of the cellular metabolome during human cytomegalovirus infection. PLoS Pathogens.2:1165. 2006;2:1165
30. Hess, D. C., Lu, W., Rabinowitz, J. D., Botstein, D. Ammonium toxicity and potassium limitation in yeast. PLoS Biology.4:2012-2023. 2006;4:2012-2023
29. Kimball, E., Rabinowitz, J. D. Identifying decomposition products in extracts of cellular metabolites. Anal. Biochem.. 358:273-80. 2006.
28. Yuan, J., Fowler, W. U., Kimball, E., Lu, W., Rabinowitz, J. D. Kinetic flux profiling of nitrogen assimilation in Escherichia coli. Nature Chem. Biol.. 2:529-530. 2006.
27. Bajad, S. U., Lu, W., Kimball, E. H., Yuan, J., Peterson, C., Rabinowitz, J. D. Separation and quantitation of water soluble cellular metabolites by hydrophilic interaction chromatography-tandem mass spectrometry. J. Chrom. A.. 1125:76-88. 2006.
26. Rabinowitz, J. D., Lloyd, P. M., Munzar, P., Myers, D. J., Cross, S., Damani, R., Quintana, R., Spyker, D. A., Soni, P., Cassella, J. V. Ultra-fast absorption of amorphous pure drug aerosols via deep lung inhalation. J. Pharm. Sci.. 95:2438-2451. 2006.
25. Lu, W., Kimball, E., Rabinowitz, J. D. A high-performance liquid chromatography-tandem mass spectrometry method for quantitation of nitrogen-containing intracellular metabolites. J. Am. Soc. Mass Spectr.. 17:37-50. 2006.
24. Rabinowitz, J. D., Wensley, M., Lloyd, P., Myers, D., Shen, W., Lu, A., Hodges, C., Hale, R., Mufson, D., Zaffaroni, A. Fast onset medications through thermally generated aerosols. J. Pharmacol. Exp. Ther.. 309:769-775. 2004.
23. Turner-Cobb, J. M., Koopman, C., Rabinowitz, J. D., Terr, A. I., Sephton, S. E., Spiegel, D. The interaction of social network size and stressful life events predict delayed-type hypersensitivity among women with metastatic breast cancer. Int. J. Psychophysiol.. 54:241-249. 2004.
22. Hall, F. C., Rabinowitz, J. D., Busch, R., Visconti, K. C., Belmares, M., Patil, N. S., Cope, A. P., Patel, S., McConnell, H. M., Mellins, E. D., Sonderstrup, G. Relationship between kinetic stability and immunogenicity of HLA-DR4/peptide complexes. Eur. J. Immunol.. 32:662-670. 2002.
21. Patil, N. S., Pashine, A., Belmares, M. P., Liu, W., Kaneshiro, B., Rabinowitz, J., McConnell, H., Mellins, E. D. Rheumatoid arthritis (RA)-associated HLA-DR alleles form less stable complexes with class II-associated invariant chain peptide than non-RA-associated HLA-DR alleles. J. Immunol.. 167:7157-7168. 2001.
20. Belmares, M. P., Rabinowitz, J. D., Lui, W., Mellins, E. D., McConnell, H. M. pH stability of HLA-DR4 complexes with antigenic peptides. Biochemistry.39:14558-14566. 2000;39:14558-14566
19. Kasson, P. M., Rabinowitz, J. D., Schmitt, L., Davis, M. M., McConnell, H. M. Kinetics of peptide binding to the class II MHC protein I-Ek. Biochemistry.39:1048-1058. 2000;39:1048-1058
18. Rabinowitz, J. D., Vrljic, M., Kasson, P. M., Liang, M. N., Busch, R., Boniface, J. J., Davis, M. M., McConnell, H. M. Formation of a highly peptide-receptive state of class II MHC. Immunity.9:699-709. 1998;9:699-709
17. Boniface, J. J., Rabinowitz, J. D., Wulfing, C., Hampl, J., Reich, Z., Altman, J. D., Kantor, R. M., Beeson, C., McConnell, H. M., Davis, M. M. Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands. Immunity.9:459-466. 1998;9:459-466
16. Lee, C., Liang, M. N., Tate, K. M., Rabinowitz, J. D., Beeson, C., Jones, P. P., McConnell, H. M. Evidence that the autoimmune antigen myelin basic protein (MBP) Ac1-9 binds towards one end of the major histocompatibility complex (MHC) cleft. J. Exp. Med.. 187:1505-1516. 1998.
15. Rabinowitz, J. D., Vacchino, J. F., Beeson, C., McConnell, H. M. Potentiometric measurement of intracellular redox activity. J. Am. Chem. Soc.. 120:2464-2473. 1998.
14. Petros, W. P., Rabinowitz, J., Gibbs, J. P., Hall, I. H., Stuart, A. R., Peters, W. P. Effect of plasma TNF-? on filgrastim-stimulated hematopoiesis in mice and humans. Pharmacotherapy.18:816-823. 1998;18:816-823
13. Rabinowitz, J. D., Liang, M. N., Tate, K., Lee, C., Beeson, C., McConnell, H. M. Specific T cell recognition of kinetic isomers in the binding of peptide to class II major histocompatibility complex. Proc. Natl. Acad. Sci. USA. 94:8702-8707. 1997.
12. Rabinowitz, J. D., Rigler, P., Carswell-Crumpton, C., Beeson, C., McConnell, H. M. Screening for novel drug effects with a microphysiometer: a potent effect of clofilium unrelated to potassium channel blockade. Life Sci..61:PL87-PL94. 1997;61:PL87-PL94
11. Elkordy, M., Crump, M., Vredenburgh, J. J., Petros, W. P., Hussein, A., Rubin, P., Ross, M., Gilbert, C., Modlin, C., Meisenberg, B., Coniglio, D., Rabinowitz, J., Laughlin, M., Kurtzberg, J., Peters, W. P. A phase I trial of recombinant human interleukin-1 beta (OCT-43) following high-dose chemotherapy and autologous bone marrow transplantation. Bone Marrow Transpl..19:315-322. 1997;19:315-322
10. Petros, W. P., Rabinowitz, J., Stuart, A., Peters, W. P. Clinical pharmacology of filgrastim following high-dose chemotherapy and autologous bone marrow transplantation. Clin. Cancer Res.. 3:705-711. 1997.
9. Wulfing, C., Rabinowitz, J. D., Beeson, C., Sjaastad, M. D., McConnell, H. M., Davis, M. M. Kinetics and extent of T cell activation as measured with the calcium signal. J. Exp. Med.. 185:1815-1825. 1997.
8. Rabinowitz, J. D., Beeson, C., Wulfing, C., Tate, K., Allen, P. M., Davis, M. M., McConnell, H. M. Altered T cell receptor ligands trigger a subset of early T cell signals. Immunity.5:125-135. 1996;5:125-135
7. Rabinowitz, J. D., Beeson, C., Lyons D. S., Davis, M. M., McConnell, H. M. Kinetic discrimination in T-cell activation. Proc. Natl. Acad. Sci. USA. 93:1401-1405. 1996.
6. Beeson, C., Rabinowitz, J., Tate, K., Gutgemann, I., Chien, Y. H., Jones, P. P., Davis, M. M., McConnell, H. M. Early biochemical signals arise from low affinity TCR-ligand reactions at the cell-cell interface. J. Exp. Med.. 184:777-782. 1996.
5. Petros, W. P., Rosner, G. L., Rabinowitz, J., Gilbert, C. J., Coniglio, D., Vredenburgh, J. J., Ross, M., Peters, W. P. The pharmacologic effects of recombinant, human colony-stimulating factors and their modulation by theophylline. Pharmacotherapy.16:742-748. 1996;16:742-748
4. Petros, W. P., Rabinowitz, J., Stuart A. R., Gupton, C., Alderman, E. M., Peters, W. P. Elevated endogenous serum macrophage colony-stimulating factor in the early stage of fungemia following bone marrow transplantation. Exp. Hematol.. 22:582-586. 1994.
3. Rabinowitz, J., Petros, W. P., Peters, W. P. Cytokine kinetics: Clinical pharmacology studies complementing recombinant growth factor trials. Cancer Bulletin.46:40-47. 1994;46:40-47
2. Rabinowitz, J., Petros, W. P., Stuart, A. R., Peters, W. P. Characterization of endogenous cytokine concentrations after high-dose chemotherapy with autologous bone marrow support. Blood.81:2452-2459. 1993;81:2452-2459
1. Petros W. P., Rabinowitz, J., Stuart, A. R., Gilbert, C. J., Kanakura, Y., Griffin, J. D., Peters, W. P. Disposition of recombinant human granulocyte-macrophage colony-stimulating factor in patients receiving high-dose chemotherapy and autologous bone marrow support. Blood.80:1135-1140. 1992;80:1135-1140