Publications

304. Xu, X., Chen, Z., Bartman, C. R., Xing, X., Olszewski, K., & Rabinowitz, J. D. (2024). One-carbon unit supplementation fuels purine synthesis in tumor-infiltrating T cells and augments checkpoint blockade. Cell chemical biology, 31(5), 932–943.e8. doi: 10.1016/

303. Lu, W., McBride, M. J., Lee, W. D., Xing, X., Xu, X., Li, X., Oschmann, A. M., Shen, Y., Bartman, C., & Rabinowitz, J. D. (2024). Selected Ion Monitoring for Orbitrap-Based Metabolomics. Metabolites, 14(4), 184. doi: 10.3390/metabo14040184

302. Chain, C., Sheehan, J. P., Xu, X., Ghaffari, S., Godbole, A., Kim, H., Freundlich, J. S., Rabinowitz, J. D., & Gitai, Z. (2024). A folate inhibitor exploits metabolic differences in Pseudomonas aeruginosa for narrow-spectrum targeting. Nature microbiology, 9(5), 1207–1219. doi: 10.1038/s41564-024-01665-2

301. Wilson, E. N., Wang, C., Swarovski, M. S., Zera, K. A., Ennerfelt, H. E., Wang, Q., Chaney, A., Gauba, E., Ramos Benitez, J. A., Le Guen, Y., Minhas, P. S., Panchal, M., Tan, Y. J., Blacher, E., A Iweka, C., Cropper, H., Jain, P., Liu, Q., Mehta, S. S., Zuckerman, A. J., … Andreasson, K. I. (2024). TREM1 disrupts myeloid bioenergetics and cognitive function in aging and Alzheimer disease mouse models. Nature neuroscience, 27(5), 873–885. doi: 10.1038/s41593-024-01610-w

300. Bowman, C. E., Neinast, M. D., Jang, C., Patel, J., Blair, M. C., Mirek, E. T., Jonsson, W. O., Chu, Q., Merlo, L., Mandik-Nayak, L., Anthony, T. G., Rabinowitz, J. D., & Arany, Z. (2024). Off-target depletion of plasma tryptophan by allosteric inhibitors of BCKDK. bioRxiv : the preprint server for biology, 2024.03.05.582974. doi: 10.1101/2024.03.05.582974

299. Shen, Y., Dinh, H. V., Cruz, E. R., Chen, Z., Bartman, C. R., Xiao, T., Call, C. M., Ryseck, R. P., Pratas, J., Weilandt, D., Baron, H., Subramanian, A., Fatma, Z., Wu, Z. Y., Dwaraknath, S., Hendry, J. I., Tran, V., Yang, L., Yoshikuni, Y., Zhao, H., Maranas, C. D., Wühr, M., Rabinowitz, J. D. (2024) Mitochondrial ATP generation is more proteome efficient than glycolysis. Nat Chem Biol., 2024 Mar 6. doi: 10.1038/s41589-024-01571-y. Online ahead of print.

298. Uehara, K., Lee, W. D., Stefkovich, M., Biswas, D., Santoleri, D., Garcia, Whitlock A. E., Quinn, Iii W. J., Coopersmith, T. N., Creasy, K. T., Rader, D. J., Sakamoto, K., Rabinowitz, J. D., Titchenell, P. M. (2024) mTORC1 controls murine postprandial hepatic glycogen synthesis via Ppp1r3b. J Clin Invest., Jan 30:e173782. doi: 10.1172/JCI173782. Online ahead of print.

297. McBride, M. J., Hunter, C. J., Zhang, Z., TeSlaa, T., Xu, X., Ducker, G. S., Rabinowitz, J. D. (2024) Glycine homeostasis requires reverse SHMT flux. Cell Metab., 36(1):103-115.e4.

296. Bartman, C. R., Faubert, B., Rabinowitz, J. D., DeBerardinis, R. J. (2023) Metabolic pathway analysis using stable isotopes in patients with cancer. Nat Rev Cancer, 23(12): 863-878.

295. Lu, W., Park, N. R., TeSlaa, T., Jankowski, C. S. R., Samarah, L., McReynolds, M., Xing, X., Schembri, J., Woolf, M. T., Rabinowitz, J. D., Davidson, S. M. (2023) Acidic Methanol Treatment Facilitates Matrix-Assisted Laser Desorption Ionization-Mass Spectrometry Imaging of Energy Metabolism. Anal Chem., 95(40):14879-14888.

294. Tran, V. G., Mishra, S., Bhagwat, S. S., Shafaei, S., Shen, Y., Allen, J. L., Crosly, B. A., Tan, S. I., Fatma, Z., Rabinowitz, J. D. Guest, J. S., Singh, V., Zhao, H. (2023) An end-to-end pipeline for succinic acid production at an industrially relevant scale using Issatchenkia orientalis. Nat Commun., 14(1): 6152.

293. Zhang, X., Lee, W. D., Leitner, B. P., Zhu, W., Fosam, A., Li, Z,, Gaspar, R. C., Halberstam, A. A., Robles, B., Rabinowitz, J. D., Perry, R. J. (2023) Dichloroacetate as a novel pharmaceutical treatment for cancer-related fatigue in melanoma. Am J Physiol Endocrinol Metab., 325(4): E363-E375.

292. Bornstein, M. R., Neinast, M. D., Zeng, X., Chu, Q., Axsom, J., Thorsheim, C., Li, K., Blair, M. C., Rabinowitz, J. D., Arany, Z. (2023) Comprehensive quantification of metabolic flux during acute cold stress in mice. Cell Metab., 2023 Sep 27 DOI: 10.1016/j.cmet.2023.09.002. 2023 Sep 27.

291. Rowe, J. H., Elia, I., Shahid, O., Gaudiano, E. F., Sifnugel, N. E., Johnson, S., Reynolds, A. G., Fung, M. E., Joshi, S., LaFleur, M. W., Park, J. S., Pauken, K. E., Rabinowitz, J. D., Freeman, G. J., Haigis, M. C., Sharpe, A. H. (2023) Formate supplementation enhances anti-tumor CD8+ T cell fitness and efficacy of PD-1 blockade. Cancer Discov., 2023 Sep 20 DOI: 10.1158/2159-8290.CD-22-1301.

290. TeSlaa, T., Ralser, M., Fan, J., Rabinowitz, J. D. (2023) The pentose phosphate pathway in health and disease. Nat Metab., 5(8): 1275-1289.

289. Leitner, B. P., Lee, W. D., Zhu, W., Zhang, X., Gaspar, R. C., Li, Z., Rabinowitz, J. D., Perry, R. J. (2023) Tissue-specific reprogramming of glutamine metabolism maintains tolerance to sepsis. PLoS One, 18(7): e0286525.

288. Zhang, K. R., Jankowski, C. S. R., Marshall, R., Nair, R., Más Gómez, N., Alnemri, A., Liu, Y., Erler, E., Ferrante, J., Song, Y., Bell, B. A., Baumann, B. H., Sterling, J., Anderson, B., Foshe, S., Roof, J., Fazelinia, H., Spruce, L. A., Chuang, J. Z., Sung, C. H., Dhingra, A., Boesze-Battaglia, K., Chavali, V. R. M., Rabinowitz, J. D., Mitchell, C. H., Dunaief, J. L. (2023) Oxidative stress induces lysosomal membrane permeabilization and ceramide accumulation in retinal pigment epithelial cells. Dis Model Mech., 16(7): dmm050066.

287. Wu, Z. Y., Sun, W., Shen, Y., Pratas, J., Suthers, P. F., Hsieh, P. H., Dwaraknath, S., Rabinowitz, J. D., Maranas, C. D., Shao, Z., Yoshikuni, Y. (2023) Metabolic engineering of low-pH-tolerant non-model yeast, Issatchenkia orientalis, for production of citramalate. Metab Eng Commun., 16:e00220. .

286. Lee, W. D., Liang, L., AbuSalim, J., Jankowski, C. S. R., Samarah, L. Z., Neinast, M. D., Rabinowitz, J. D. (2023) Impact of acute stress on murine metabolomics and metabolic flux. Proc Natl Acad Sci USA, 120(21):e2301215120. .

285. Zhang, Z., TeSlaa, T., Rabinowitz, J. D.. (2023) Reply to: revisiting the role of serine metabolism in hepatic lipogenesis. Nat. Metab., 5(5): 762-764.

284. Blair, M. C., Neinast, M. D., Jang, C., Chu, Q., Jung, J. W., Axsom, J., Bornstein, M. R., Thorsheim, C., Li, K., Hoshino, A., Yang, S., Roth, Flach R. J., Zhang, B. B., Rabinowitz, J. D., Arany, Z. (2023) Branched-chain amino acid catabolism in muscle affects systemic BCAA levels but not insulin resistance. Nat Metab,, 5(4): 589-606.

283. Bartman, C. R., Weilandt, D. R., Shen, Y., Lee, W. D., Han, Y., TeSlaa, T., Jankowski, C. S. R., Samarah, L., Park, N. R., da Silva-Diz, V., Aleksandrova, M., Gultekin, Y., Marishta, A., Wang, L., Yang, L., Roichman, A., Bhatt, V., Lan, T., Hu, Z., Xing, X., Lu, W., Davidson, S., Wühr, M., Vander Heiden, M. G., Herranz, D., Guo, J. Y., Kang, Y., Rabinowitz, J. D. (2023) Slow TCA flux and ATP production in primary solid tumours but not metastases. Nature, 614(7947): 349-357.

282. Hu, M., Dinh, H. V., Shen, Y., Suthers, P. F., Foster, C. J., Call, C. M., Ye, X., Pratas, J., Fatma, Z., Zhao, H., Rabinowitz, J. D., Maranas, C. D. (2023) Comparative study of two Saccharomyces cerevisiae strains with kinetic models at genome-scale. Metab Eng., 76: 1-17..

281. Meyer, C. F., Seath, C. P., Knutson, S. D., Lu, W., Rabinowitz, J. D., MacMillan, D. W. C. (2022) Photoproximity Labeling of Sialylated Glycoproteins (GlycoMap) Reveals Sialylation-Dependent Regulation of Ion Transport. J Am Chem Soc., 144: 23633-23641.

280. Chellappa, K., McReynolds, M. R., Lu, W., Zeng, X., Makarov, M., Hayat, F., Mukherjee, S., Bhat, Y. R., Lingala, S. R., Shima, R. T., Descamps, H. C., Cox ,T., Ji, L., Jankowski, C., Chu, Q., Davidson, S. M., Thaiss, C. A., Migaud, M. E., Rabinowitz, J. D., Baur, J. A. (2022) NAD precursors cycle between host tissues and the gut microbiome. Cell Metab., 34: 1947-1959.e5.

279. Zhao, H., Teng, D., Yang, L., Xu, X., Chen, J., Jiang, T., Feng, A. Y., Zhang, Y., Frederick, D. T., Gu, L., Cai, L., Asara, J. M., Pasca di Magliano, M., Boland, G. M., Flaherty, K. T., Swanson, K. D., Liu, D., Rabinowitz, J. D., Zheng, B. (2022) Myeloid-derived itaconate suppresses cytotoxic CD8+ T cells and promotes tumour growth. Nat Metab., 4: 1660-1673.

278. Xiao, T., Khan, A., Shen, Y., Chen, L., Rabinowitz, J. D. (2022) Glucose feeds the tricarboxylic acid cycle via excreted ethanol in fermenting yeast. Nat Chem Biol., 18: 1380-1387.

277. Murashige, D., Jung, J. W., Neinast, M. D., Levin, M. G., Chu, Q., Lambert, J. P., Garbincius, J. F., Kim, B., Hoshino, A., Marti-Pamies, I., McDaid, K. S., Shewale, S. V., Flam, E., Yang, S., Roberts, E., Li, L., Morley, M. P., Bedi, K. C. Jr, Hyman, M. C., Frankel, D. S., Margulies, K. B., Assoian, R, K,, Elrod, J. W., Jang, C., Rabinowitz, J. D., Arany, Z. (2022) Extra-cardiac BCAA catabolism lowers blood pressure and protects from heart failure. Cell Metab., 34: 1749-1764.e7.

276. Jankowski, C. S. R., Rabinowitz, J. D. (2022) Selenium modulates cancer cell response to pharmacologic ascorbate. Cancer Res., 82: 3486-3498.

275. Jang, C., Hui, S., Zeng, X., Cowan, A. J., Wang, L., Chen, L., Morscher, R. J., Reyes, J., Frezza, C., Hwang, H. Y., Imai, A., Saito, Y., Okamoto, K., Vaspoli, C., Kasprenski, L., Zsido, G. A. 2nd, Gorman, J. H. 3rd, Gorman, R. C., Rabinowitz, J. D. (2022) Metabolite Exchange between Mammalian Organs Quantified in Pigs. Cell Metab., 34:1410.

274. Zeng, X., Xing, X., Gupta, M., Keber, F. C., Lopez, J. G., Lee, Y. J., Roichman, A., Wang, L., Neinast, M. D., Donia, M. S., Wühr, M., Jang, C., Rabinowitz, J. D. (2022) Gut bacterial nutrient preferences quantified in vivo. Cell, 185: 3441-3456.e19.

273. Zhang, Y., Xu, Y., Lu, W., Li, J., Yu, S., Brown, E. J., Stanger, B. Z., Rabinowitz, J. D., Yang, X. (2022) G6PD-mediated increase in de novo NADP+ biosynthesis promotes antioxidant defense and tumor metastasis. Sci Adv, 8: eabo0404.

272. Lindell, R. B., Zhang, D., Bush, J., Wallace, D. C., Rabinowitz, J. D., Lu, W., Wherry, E. J., Weiss, S. L., Henrickson, S. E.(2022) Impaired Lymphocyte Responses in Pediatric Sepsis Vary by Pathogen Type and Are Associated with Features of Immunometabolic Dysregulation. Shock, 57: 191-199.

271. Olszewski, K., Barsotti, A., Feng, X. J., Momcilovic, M., Liu, K.G., Kim, J. I., Morris, K., Lamarque, C., Gaffney, J., Yu, X., Patel, J. P., Rabinowitz, J. D., Shackelford, D. B., Poyurovsky, M. V. (2022) Inhibition of glucose transport synergizes with chemical or genetic disruption of mitochondrial metabolism and suppresses TCA cycle-deficient tumors. Cell Chem Biol., 29: 423-435.e.10.

270. Nofal, M., Wang, T., Yang, L., Jankowski, C. S. R., Hsin-Jung, L. S., Han, S., Parsons, L., Frese, A. N., Gitai, Z., Anthony, T. G., Wühr, M., Sabatini, D. M., Rabinowitz, J. D. (2022) GCN2 adapts protein synthesis to scavenging-dependent growth. Cell Syst., 13: 158-172.

269. Yang, L., TeSlaa, T., Ng, S., Nofal, M., Wang, L., Lan, T., Zeng, X., Cowan, A., McBride, M., Lu, W., Davidson, S., Liang, G., Oh, T. G., Downes, M., Evans, R., Von Hoff, D., Guo, J. Y., Han, H., Rabinowitz, J.D. (2022) Ketogenic diet and chemotherapy combine to disrupt pancreatic cancer metabolism and growth. Med (N Y), 3:119-136.

268. Wang, L., Xing, X., Zeng, X., Jackson, S. R., TeSlaa, T., Al-Dalahmah, O., Samarah, L. Z., Goodwin, K., Yang, L., McReynolds, M. R., Li, X., Wolff, J. J., Rabinowitz, J. D., Davidson, S. M. (2022) Spatially resolved isotope tracing reveals tissue metabolic activity. Nat Methods, 19: 223-230.

267. Green, C. L., Pak, H. H., Richardson, N. E., Flores, V., Yu, D., Tomasiewicz, J. L., Dumas, S. N., Kredell, K., Fan, J. W., Kirsh, C., Chaiyakul, K., Murphy, M. E., Babygirija, R., Barrett-Wilt, G. A., Rabinowitz, J., Ong, I. M., Jang, C., Simcox, J., Lamming, D. W. (2022) Sex and genetic background define the metabolic, physiologic, and molecular response to protein restriction. Cell Metab., 34: 209-226.e5.

266. Wilke, A. C., Doebele, C., Zindel, A., Lee, K. S., Rieke, S.A., Ceribelli, M., Comoglio, F., Phelan, J. D., Wang, J, Q., Pikman, Y., Jahn, D., Häupl, B., Schneider, C., Scheich, S., Tosto, F. A., Bohnenberger, H., Stauder, P., Schnuetgen, F., Slabicki, M., Coulibaly, Z. A., Wolf ,S., Bojarczuk, K., Chapuy, B., Brandts, C. H., Stroebel, P., Lewis, C. A., Engelke, M., Xu ,X., Kim, H., Dang, T. H., Schmitz, R., Hodson, D. J., Stegmaier, K., Urlaub, H., Serve, H., Schmitt, C. A., Kreuz, F., Knittel, G., Rabinowitz, J. D., Reinhardt, H. C., Vander Heiden, M. G., Thomas, C., Staudt, L. M., Zenz, T., Oellerich, T. (2022) SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma. Blood, 139: 538-553.

265. Sugiura, A., Andrejeva, G., Voss, K., Heintzman, D. R., Xu, X., Madden, M. Z., Ye, X., Beier, K. L., Chowdhury, N. U., Wolf, M. M., Young, A. C., Greenwood, D. L., Sewell, A. E., Shahi, S. K., Freedman, S. N., Cameron, A. M., Foerch, P., Bourne, T., Garcia-Canaveras, J. C., Karijolich, J., Newcomb, D. C., Mangalam, A. K., Rabinowitz, J. D., Rathmell, J. C. (2022) MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function. Immunity, 55: 65-81.e9.

264. Li, X., Hui, S., Mirek, E. T., Jonsson, W. O., Anthony, T. G., Lee, W. D., Zeng, X., Jang, C., Rabinowitz, J. D. (2022) Circulating metabolite homeostasis achieved through mass action. Nat Metab., 4: 141-152.

263. Zhang, Z., TeSlaa, T., Xu, X., Zeng, X., Yang, L., Xing, G., Tesz, G. J., Clasquin, M. F., Rabinowitz, J. D. (2021) Serine catabolism generates liver NADPH and supports hepatic lipogenesis. Nat Metab., 3: 1608-1620.

262. Ghergurovich, J. M., Xu, X., Wang, J. Z., Yang, L., Ryseck, R. P., Wang, L., Rabinowitz, J. D. (2021) Methionine synthase supports tumour tetrahydrofolate pools. Nat Metab., 3: 1512-1520.

261. Ding H, Chen Z, Wu K, Huang SM, Wu WL, LeBoeuf SE, Pillai RG, Rabinowitz JD, Papagiannakopoulos T. (2021) Activation of the NRF2 antioxidant program sensitizes tumors to G6PD inhibition. Sci Adv., 7: eabk1023.

260. Chen, L., Lu, W., Wang, L., Xing, X., Chen, Z., Teng, X., Zeng, X., Muscarella, A. D., Shen, Y., Cowan, A., McReynolds, M. R., Kennedy, B. J., Lato, A. M., Campagna, S. R., Singh, M., Rabinowitz, J. D. (2021) Metabolite discovery through global annotation of untargeted metabolomics data. Nat Methods, 18:1377-1385.

259. Parkhitko, A. A., Wang, L., Filine, E., Jouandin, P., Leshchiner, D., Binari, R., Asara, J. M., Rabinowitz, J. D., Perrimon, N. (2021) A genetic model of methionine restriction extends Drosophila health- and lifespan. Proc Natl Acad Sci U S A, 118(40):e2110387118.

258. Garcia-Canaveras, J. C., Heo, D., Trefely, S., Leferovich, J., Xu, C., Philipson, B. I., Ghassemi, S., Milone, M. C., Moon, E. K., Snyder, N. W., June, C. H., Rabinowitz, J. D., O'Connor, R. S. (2021) CAR T-Cells Depend on the Coupling of NADH Oxidation with ATP Production. Cells., 10: 2334.

257. McReynolds, M. R., Chellappa, K., Chiles, E., Jankowski, C., Shen, Y., Chen, L., Descamps, H. C., Mukherjee, S., Bhat, Y. R., Lingala, S. R., Chu, Q., Botolin, P., Hayat, F., Doke, T., Susztak, K., Thaiss, C. A., Lu, W., Migaud, M. E., Su, X., Rabinowitz, J. D., Baur, J. A. (2021) NAD+ flux is maintained in aged mice despite lower tissue concentrations. Cell Syst., 12: 1160-1172.

256. Cable, J., Pourquié, O., Wellen, K. E., Finley, L. W. S., Aulehla, A., Gould, A. P., Teleman, A., Tu, W. B., Garrett, W. S., Miguel-Aliaga, I., Perrimon, N., Hooper, L. V., Walhout, A. J. M., Wei, W., Alexandrov, T., Erez, A., Ralser, M., Rabinowitz, J. D., Hemalatha, A., Gutiérrez-Pérez, P., Chandel, N. S., Rutter, J., Locasale, J. W., Landoni, J. C., Christofk, H. (2021) Metabolic decisions in development and disease-a Keystone Symposia report. Ann N Y Acad Sci, 1506: 55-73.

255. Phan, T., Nguyen, V. H., Buettner, R., Morales, C., Yang, L., Wong, P., Tsai, W., d'Alincourt Salazar, M., Gil, Z., Diamond, D. J., Rabinowitz, J. D., Rosen, S., Melstrom, L. G. (2021) Inhibition of de novo pyrimidine synthesis augments Gemcitabine induced growth inhibition in an immunocompetent model of pancreatic cancer. Int. J. Biol. Sci., 17: 2240-2251.

254. Bartman, C. R., TeSlaa, T., Rabinowitz, J. D. (2021) Quantitative flux analysis in mammals. Nat Metab., 3:896-908.

253. Ghergurovich, J. M., Lang, J. D., Levin, M. K., Briones, N., Facista, S. J., Mueller, E. S. C., Cowan, A. J., McBride, M. J., San Roman Rodriguez, E., Killian, A., Dao, T., Lamont, J., Barron, A., Su, X., Hendricks, W. P. D., Espina, V., Von Hoff, D. D. O'Shaughnessy, J., Rabinowitz, J. D. (2021) Local production of lactate, ribose phosphate, and amino acids within human triple-negative breast cancer. Med (NY), 2: 736-754.

252. Schild, T., McReynolds, M. R., Shea, C., Low, V., Schaffer, B. E., Asara, J. M., Piskounova, E., Dephoure, N., Rabinowitz, J. D., Gomes, A. P., Blenis, J. (2021) NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinoma. Cell Rep, 35: 109238.

251. Li, S. H-J., Nofal, M., Parsons, L. R., Rabinowitz, J. D., Gitai, Z. (2021) Monitoring mammalian mitochondrial translation with MitoRiboSeq. Nat Protoc, 16: 2802-2825.

250. Yu, D., Richardson, N. E., Green, C. L., Spicer, A. B., Murphy, M. E., Flores, V., Jang, C., Kasza, I., Nikodemova, M., Wakai, M. H., Tomasiewicz, J. L., Yang, S. E., Miller, B. R., Pak, H. H., Brinkman, J. A., Rojas, J. M., Quinn 3rd, W. J., Cheng, E. P., Konon, E. N., Haider, L. R., Finke, M., Sonsalla, M., Alexander, C. M., Rabinowitz, J. D., Baur, J. A., Malecki, K. C., Lamming, D. W. (2021) The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine. Cell Metab, 33: 905-922.e6.

249. Cho, S., Lee, G., Pickering, B. F., Jang, C., Park, J. H., He, L., Mathur, L., Kim, S-S., Jung, S., Tang, H-W., Monette, S., Rabinowitz, J. D., Perrimon, N., Jaffrey, S. R., Blenis, J. (2021) mTORC1 promotes cell growth via m 6 A-dependent mRNA degradation. Mol Cell, 81: 2064-2075.

248. Minhas, P. S., Latif-Hernandez, A., McReynolds, M. R., Durairaj, A. S., Wang, Q., Rubin, A., Joshi, A. U., He, J. Q., Gauba, E., Liu, L., Wang, C., Linde, M., Sugiura, Y., Moon, P. K., Majeti, R., Suematsu, M., Mochly-Rosen, D., Weissman, I. L., Longo, F. M., Rabinowitz, J. D., Andreasson, K. I. (2021) Restoring metabolism of myeloid cells reverses cognitive decline in ageing. Nature, 590: 122-128.

247. TeSlaa, T., Bartman, C. R., Jankowski, C. S. R., Zhang, Z., Xu, X., Xing, X., Wang, L., Lu, W., Hui, S., Rabinowitz, J. D. (2021) The Source of Glycolytic Intermediates in Mammalian Tissues. Cell Metab, 33: 367-378.e5.

246. García-Cañaveras, J. C., Lancho, O., Ducker, G. S., Ghergurovich, J. M., Xu, X., da Silva-Diz, V., Minuzzo, S., Indraccolo, S., Kim, H., Herranz, D., Rabinowitz, J. D. (2021) SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia. Leukemia, 35:377-388.

245. Parkhitko, A. A., Ramesh, D., Wang, L., Leshchiner, D., Filine, E., Binari, R., Olsen, A. L., Asara, J. M., Cracan, V., Rabinowitz, J. D., Brockmann, A., Perrimon, N. (2020) Downregulation of the tyrosine degradation pathway extends Drosophila lifespan. Elife, 9:e58053.

244. Ringel, A. E, Drijvers, J.M., Baker, G. J., Catozzi, A., García-Cañaveras, J. C., Brandon M Gassaway, B. M., Miller, B. C., Juneja, V. R., Nguyen, T. H., Joshi, S., Yao, C-H., Yoon, H., Sage, P. T., LaFleur, M. W., Trombley, J. D., Jacobson, C. A., Maliga, Z., Gygi, S. P., Sorger, P.K., Rabinowitz, J. D., Sharpe, A. H., Haigis, M. C. (2020) Obesity shapes metabolism in the tumor microenvironment to suppress anti-tumor immunity. Cell, S0092-8674(20)31526-9.

243. Chini, C. C. S., et. al. (2020) CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD + and NMN levels. Nat Metab., 2:1284-1304.

242. Zhang, Y., Xu, Y., Lu, W., Ghergurovich, J. M., Guo, L., Blair, I. A., Rabinowitz, J. D., Yang, X. (2020) Upregulation of antioxidant capacity and nucleotide precursor availability suffices for oncogenic transformation. Cell Metab., S1550-4131(20)30535-0.

241. Suthers, P. F., Dinh, H. V., Fatma, Z., Shen, Y., Chan, S. H. J., Rabinowitz, J. D., Zhao, H., Maranas, C. D. (2020) Genome-scale metabolic reconstruction of the non-model yeast Issatchenkia orientalis SD108 and its application to organic acids production. Metab Eng Commun, 11: e00148.

240. Murashige, D., Jang, C., Neinast, M., Edwards, J. J., Cowan, A., Hyman, M. C., Rabinowitz, J. D., Frankel, D. S., Arany, Z. (2020) Comprehensive quantification of fuel use by the failing and nonfailing human heart. Science, 370(6514): 364-368.

239. Luongo, T. S., Eller, J. M., Lu, M-J., Niere, M., Raith, F., Perry, C., Bornstein, M. R., Oliphint, P., Wang, L., McReynolds, M. R., Migaud, M. E., Rabinowitz, J. D., Johnson, F. B., Johnsson K., Ziegler, M., Cambronne, X. A., Baur, J. A. (2020) SLC25A51 is a mammalian mitochondrial NAD + transporter. Nature, 588: 174-179.

238. Green, R., Sonal, Wang, L., Hart, S. F. M., Lu, W., Skelding, D., Burton, J. C., Mi, H., Capel, A., Chen, H. A., Lin, A., Subramaniam, A. R., Rabinowitz, J. D., Shou, W. (2020) Metabolic excretion associated with nutrient-growth dysregulation promotes the rapid evolution of an overt metabolic defect. PLoS Biol., 18: e3000757.

237. Hui, S., Cowan, A. J., Zeng, X., Yang, L., TeSlaa, T., Li, X., Bartman, C., Zhang, Z., Jang, C., Wang, L., Lu, W., Rojas, J., Baur, J., Rabinowitz, J. D. (2020) Quantitative fluxomics of circulating metabolites. Cell Metab., 32: 676-688.e4.

236. Ghassemi, S., Martinez-Becerra, F. J., Master, A. M., Richman, S. A., Heo, D., Leferovich, J., Tu, Y., García-Cañaveras, J. C., Ayari, A., Lu, Y., Wang, A., Rabinowitz, J. D., Milone, M. C., June, C. H., O'Connor, R. S. (2020) Enhancing chimeric antigen receptor T cell anti-tumor function through advanced media design. Mol. Ther. Methods Clin. Dev., 18: 595-606.

235. Poillet-Perez, L., Sharp, D.W., Yang, Y., Laddha, S. V., Ibrahim, M., Bommareddy, P. K., Hu, Z. S., Vieth, J., Haas, M., Bosenberg, M. W., Rabinowitz, J. D., Cao, J., Guan, J.-L., Ganesan, S., Chan, C. S., Mehnert, J. M., Lattime, E. C., White, E. (2020) Autophagy promotes growth of tumors with high mutational burden by inhibiting a T-cell immune response. Nat Cancer 1, 923–934.

234. Guan, D., Xiong, Y., Trinh, T. M., Xiao, Y., Hu, W., Jiang, C., Dierickx, P., Jang, C., Rabinowitz, J. D., Lazar, M. A. (2020) The hepatocyte clock and feeding control chronophysiology of multiple liver cell types. Science, 369: 1388-1394.

233. Xu, Y., Zhang, Y., García-Cañaveras, J. C., Guo, L., Kan, M., Yu, S., Blair, I. A., Rabinowitz, J. D., Yang, X. (2020) Chaperone-mediated autophagy regulates the pluripotency of embryonic stem cells. Science, 369: 397-403.

232. Rabinowitz, J. D., Enerbäck, S. (2020) Lactate: the ugly duckling of energy metabolism. Nature Metab., 2: 566-571.

231. Jang, C., Wada, S., Yang, S., Gosis, B., Zeng, X.,Zhang, Z., Shen, Y., Lee, G., Arany, Z. Rabinowitz, J. D. (2020) The small intestine shields the liver from fructose-induced steatosis. Nat Metab., 2: 586-593.

230. Ghergurovich, J. M., Esposito, M., Chen, Z., Wang, W. Z., Bhatt, V., Lan, T., White, E., Kang, Y., Guo, J. Y., Rabinowitz, J. D. (2020) Glucose-6-phosphate dehydrogenase is not essential for K-Ras-driven tumor growth or metastasis. Cancer Res., 80: 3820-3829.

229. Lu, W., Xing, X., Wang, L., Chen, L., Zhang, S., McReynolds, M. R., Rabinowitz, J. D. (2020) Improved annotation of untargeted metabolomics data through buffer modifications that shift adduct mass and intensity. Anal Chem., 92: 11573-11581.

228. Martin 2nd, J. K., Sheehan, J. P., Bratton, B. P., Moore, G. M., Mateus, A., Li, S. H.-J., Kim, H., Rabinowitz, J. D., Typas,A., Savitski, M. M., Wilson, M. Z., Gitai, Z. (2020) A dual-mechanism antibiotic kills gram-negative bacteria and avoids drug resistance. Cell, 181: 1518-1532.e14.

227. Gibney, P. A., Chen, A., Schieler, A., Chen, J. C., Xu, Y., Hendrickson, D. G., McIsaac, R. S., Rabinowitz, J. D., Botstein, D. (2020) A tps1Δ persister-like state in saccharomyces cerevisiae is regulated by MKT1. PLoS One, 15: e0233779.

226. Ghergurovich, J. M., García-Cañaveras, J. C., Wang, J., Schmidt, E., Zhang, Z., TeSlaa, T., Patel, H., Chen, L., Britt, E. C., Piqueras-Nebot, M., Gomez-Cabrera, M. C., Lahoz, A., Fan, J., Beier, U. H., Kim, H., Rabinowitz, J. D. (2020) A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway. Nat Chem Biol., 16: 731-739.

225. Zhao, S., Jang, C., Liu, J., Uehara, K., Gilbert, M., Izzo, L., Zeng, X., Trefely, S., Fernandez, S., Carrer, A., Miller, K. D., Zhug, Z. T., Snyder, N. W., Gade, T. P., Titchenell, P. M., Rabinowitz, J. D., Wellen, K. E., (2020) Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate. Nature, 579: 586-591.

224. Yang, L., García-Cañaveras, J. C., Chen, Z., Wang, L., Liang, L., Jang, C., Mayr, J. A., Zhang, Z., Ghergurovich, J. M., Zhan, L., Joshi, S., Hu, Z., McReynolds, M. R., Su, X., White, E., Morscher, R. J., Rabinowitz, J. D. (2020) Serine catabolism feeds NADH when respiration is impaired. Cell Metab., 31: 809-821.e6.

223. Hermans, D., Gautam, S., García-Cañaveras, J. C.,Gromer, D., Mitra, S., Spolski, R., Li, P., Christensen, S., Nguyen, R., Lin, J. X., Oh, J., Du, N., Veenbergen, S., Fioravanti, J., Ebina-Shibuya, R., Bleck, C., Neckers, L. M., Rabinowitz, J. D., Gattinoni, L., Leonard, W. J. (2020) Lactate dehydrogenase inhibition synergizeswith IL-21 to promote CD8+ T cell stemness and antitumor immunity. Proc Natl Acad Sci USA, 117: 6047-6055.

222. Li, A. M., Ducker, G. S., Li, Y., Seoane, J. A., Xiao, Y., Melemenidis, S., Zhou, Y., Liu, L., Vanharanta, S., Graves, E. E., Rankin, E. B., Curtis, C., Massagué, J., Rabinowitz, J. D., Thompson, C. B., Ye, J. (2020) Metabolic profiling reveals a dependency of humanmetastatic breast cancer on mitochondrial serine and one-carbon metabolism. Mol Cancer Res., 18: 599-611.

221. Gokhale, S., Lu, W., Zhu, S., Liu, Y., Hart, R. P., Rabinowitz, J. D., Xie, P. (2019) Elevated choline kinase α-mediated choline metabolism supports the prolonged survival of TRAF3-deficient B lymphocytes. J Immunol., 204: 459-471.

220. Estrella, M. A., Du, J., Chen, L., Rath, S., Prangley, E., Chitrakar, A., Aoki, T., Schedl, P., Rabinowitz, J., Korennykh, A. (2019) The metabolites NADP and NADPH are the targets of the circadian protein nocturnin (curled). Nat Commun., 10: 2367.

219. Dinh, H. V., Suthers, P. F., Chan, S. H. J., Shen, Y., Xiao, T., Deewan, A., Jagtap, S. S., Zhao, H., Rao, C. V., Rabinowitz, J. D., Maranas, C. D. (2019) A comprehensive genome-scale model for Rhodosporidium toruloides IFO0880 accounting for functional genomics and phenotypic data. Metab Eng Commun., 9: e00101.

218. Benson, K. K., Hu, W., Weller, A. H., Chen, E. R., Khetarpal, S. A., Yoshino, S., Bone, W. P., Wang, L., Rabinowitz, J. D., Voight, B. F., Soccio, R. E. (2019) . Natural human genetic variation determines basal and inducible expression of PM20D1, an obesity-associated gene. Proc Natl Acad Sci USA, 116: 23232-23242.

217. Park, J. O., Tanner, L. B., Wei, M. H., Khana, D. B., Jacobson, T. B., Zhang, Z., Rubin, S. A., Li, S. H., Higgins, M. B., Stevenson, d. M., Amador-Noguez, D., Rabinowitz, J. D. (2019) Near-equilibrium glycolysis supports metabolic homeostasis and energy yield. Nat Chem Biol,. 15: 1001-1008.

216. Stine, R. R., Sakers, A. P., TeSlaa, T., Kissig, M., Stine, Z. E., Kwon, C. W., Cheng, L., Lim, H. W., Kaestner, K. H., Rabinowitz, J. D., Seale, P. (2019) PRDM16 maintains a homeostasis of the intestinal epithelium by controlling region-specific metabolism. Cell Stem Cell, 25: 830-845.

215. Ron-Harel, N., Ghergurovich, J. M., Notarangelo, G., LaFleur, M. W., Tsubosaka, Y., Sharpe, A., H., Rabinowitz, J. D., Haigis. M. C. (2019) T cell activation depends on extracellular alanine. Cell Rep., 28: 3011-3021.e4.

214. Bailis, W., Shyer, J. A., Zhao, J., García-Cañaveras, J. C., Al Khazal, F. J., Qu, R., Steach, H. R., Bielecki, P., Khan, O., Jackson, R., Kluger, Y., Maher. L. J. 3rd, Rabinowitz, J., Craft, J., Flavell, R. A. (2019) Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function. Nature, 571: 403-407.

213. Dekhne, A. S., Shah, K., Ducker, G. S., Katinas, J. M., Wong-Roushar, J., Nayeen, M. J., Doshi, A., Ning, C., Bao, X., Frühauf, J., Liu, J., Wallace-Povirk, A., O'Connor, C., Dzinic, S. H., White, K., Kushner, J., Kim, S., Hüttermann, M., Polin, L., Rabinowitz, J. D., Li, J., Hou, Z., Dann, C. E., Gangjee, A., Matherly, L. H. (2019) Novel pyrrolo[3,2-d]pyrimidine compounds target mitochondrial and cytosolic one-carbon metabolism with broad-spectrum antitumor efficacy. Mol Cancer Ther., 18: 1787-1799.

212. Liu, Q., Johnson, E. M.. Lam, R. K., Wang, Q., Bo, Ye H., Wilson, E. N., Minhas, P. S., Liu,L., Swarovski, M. S., Tran, S., Wang, J., Mehta, S. S., Yang, X., Rabinowitz, J. D., Yang, S. S., Shamloo, M., Mueller, C., James, M. L., Andreasson, K. I. (2019) . Peripheral TREM1 responses to brain and intestinal immunogens amplify stroke severity. Nat Metab., 20: 1023-1034.

211. Jang, C., Hui, S., Zeng, X., Cowan, A. J., Wang, L., Chen, L., Morscher, R. J., Reyes, J., Frezza,C., Hwang, H. Y., Imai, A., Saito, Y., Okamoto, K., Vaspoli, C., Kasprenski, L., Zsido, G. A. 2nd, Gorman, J. H. 3rd, Gorman, R. C., Rabinowitz, J. D. (2019) Metabolite exchange between mammalian organs quantified in pigs. Cell Metab., 30: 594-606.

210. Song, Y., Park, J. O., Tanner, L., Nagano, Y., Rabinowitz, J. D., Shvartsman, S. Y. (2019) Energy budget of Drosophila embryogenesis. Curr Biol., 29: R566-R567.

209. Schober, A. F., Mathis, A. D., Ingle, C., Park, J. O., Chen, L., Rabinowitz, J. D., Junier, I., Rivoire, O., Reynolds, K. A. (2019) A two-enzyme adaptive unit within bacterial folate metabolism. Cell Rep., 27: 3359-3370.e7.

208. García-Cañaveras, J. C., Chen, L., Rabinowitz, J. D. (2019) The tumor metobolic microenvironment: Lessons from lactate. Cancer Res., 79: 3155-3162.

207. Wang, W., Ishibashi, J., Trefely, S., Shao, M., Cowan, A. J., Sakers, A., Lim, H. W., O'Connor, S., Doan, M. T., Cohen, P., Baur, J. A., King, M. T., Veech, R. L., Won, K. J., Rabinowitz, J. D., Snyder, N. w., Gupta, R. K., Seale, P. (2019) A PRDM 16-driven metabolic signal from adipocytes regulates precursor cell fate. Cell Metab., 30: 174-189.

206. Chen, L., Zhang, Z., Hoshino, A., Zhang, H. D., Morley, M., Arany, Z., Rabinowitz, J. D. (2019) NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism. Nat. Metab., 1: 404-415.

205. Bradley, P. H., Gibney, P. A., Botstein, D., Troyanskaya, O. G., Rabinowitz, J. D. (2019) Minor isozymes tailor yeast metabolism to carbon availability. mSystems, 4(1) pii: e00170-18.

204. Rodriguez, A. E., Ducker, G. S., Billingham, L. K., Martinez, C. A., Mainolfi, N., Suri, V., Friedman, A., Manfredi, M. G., Weinberg, S. E., Rabinowitz, J. D., Chandel, N. S. (2019) Serine metabolism supports macrophage IL-1β . Cell Metab., 29: 1003-1011.

203. Wang, L., Xing, X., Chen, L., Yang, L., Su, X., Rabitz, H. A., Lu, W., Rabinowitz, J. D. (2018) Peak annotation and verification engine (PAVE) for untargeted LC-MS metabolomics. Anal. Chem., 91: 1838-1846.

202. Rabinowitz, J. D. and Mutlu, G. M. (2019) A metabolic strategy to reverse fibrosis? Nat Metab, 1: 12-13.

201. Ron-Harel, N., Notarangelo, G., Ghergurovich, J. M., Paulo, J. A., Sage, P. T., Santos, D., Satterstrom, F. K., Gygi, S. P., Rabinowitz, J. D., Sharpe, A. H., Haigis, M. C. (2018) Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice. Proc Natl Acad Sci USA, 115: 13347-13352.

200. Minhas, P. S., Liu, L., Moon, P. K., Joshi, A. U., Dove, C., Mhatre, S. Contrepois, K., Wang, Q., Lee, B. A., Coronado, M., Bernstein, D., Snyder, M. P., Migaud, M., Majeti, R., Mochly-Rosen, D., Rabinowitz, J. D., Andreasson, K. I. (2018) Macrophage de novo NAD+ synthesis specifies immune fundtion in aging and inflammation. Nat Immunol., 20: 50-63.

199. Neinast, M. D.,Jang, C., Hui, S., Murashige, D. S., Chu, Q., Morscher, R. J., Li, X., Zhan, L., White, E., Anthony, T. G., Rabinowitz, J. D., Arany, Z. (2018) Quantitative analysis of the whole-body metabolic fate of branched-chain amino acids. Cell Metab., 29: 417-429e4.

198. Poillet-Perez, L., Xie, X., Zhan, L., Yang, Y., Sharp, D. W., Hu, Z. S., Su, X., Maganti, A., Jiang, C., Zheng, H., Bosenberg, M. W., Mehnert, J. M., Guo, J. Y., Lattime, E., Rabinowitz, J. D., White, E. (2018) Autophagy maintains tumour growth through circulating arginine. Nature, 563: 569-573.

197. Xu, Y. F., Lu, W., Chen, J. C., Johnson, S. A., Gibney, P. A., Thomas, D. G., Brown, G., May, A. L., Campagna, S. R., Yakunin, A. F., Botstein, D., Rabinowitz, J. D. (2018) Discovery and functional characterization of a yeast sugar alcohol phosphatase. ACS Chem. Biol.. 13: 3011-3020.

196. Hui, S., Rabinowitz, J. D. (2018) An unexpected trigger for calorie burning in brown fat. Nature, 560: 38-39.

195. Guan, D., Xiong, Y., Borck, P. C., Jang, C., Doulias, P. T., Papazyan, R., Fang, B., Jiang, C., Zhang, Y., Briggs, E. R., Hu, W., Steger, D., Ischiropoulos, H., Rabinowitz, J. D., Lazar, M. A. (2018) Diet-Induced Circadian Enhancer Remodeling Synchronizes Opposing Hepatic Lipid Metabolic Processes. Cell, 174: 831-842.e12.

194. Li, S. H., Li, Z., Park, J. O., King, C. G., Rabinowitz, J. D., Wingreen, N. S., Gitai, Z. (2018) Escherichia coli translation strategies differ across carbon, nitrogen and phosphorus limitation conditions. Nat Microbiol., 3: 939-947.

193. Rodan, L. H., Qi, W., Ducker, G. S., Demirbas, D., Laine, R., Yang, E., Walker, M. A., Eichler, F., Rabinowitz, J. D., Anselm, I., Berry, G. T., Undiagnosed Diseases Network (UDN). (2018) 5, 10-methenyltetrahydrofolate synthetase deficiency causes a neurometabolic disorder associated with microcephaly, epilepsy, and cerebral hypomyelination. Mol Genet Metab., 125: 118-126.

192. Tanner, L. B., Goglia, A. G., Wei, M. H., Sehgal, T., Parsons, L. R., Park, J. O., White, E., Toettcher, J. E., Rabinowitz, J. D. (2018) Four key steps control glycolytic flux in mammalian cells. Cell Syst., 7: 49-62e8.

191. Davila, A., Liu, L., Chellappa, K., Redpath, P., Nakamaru-Ogiso, E., Paolella, L. M., Zhang, Z., Migaud, M. E., Rabinowitz, J. D., Baur, J. A. (2018) Nicotinamide adenine dinucleotide is transported into mammalian mitochondria. Elife, 7: pii: e33246.

190. Nofal, M. and Rabinowitz, J. D. (2018) Ribosomes on the night shift. Science, 360: 710-711.

189. Jang, C., Chen, L., Rabinowitz, J. D. (2018) Metabolomics and isotope tracing. Cell, 173: 822-837.

188. Liu, L., Su, X., Quinn, W. J. 3rd, Hui, S., Krukenberg, K., Frederick,D. W., Redpath, P., Zhan, L., Chellappa, K., White, E., Migaud, M., Mitchison, T. J., Baur, J. A., Rabinowitz, J. D. (2018) Quantitative analysis of NAD synthesis-breakdown fluxes. Cell Metab., 27: 1067-1080 e5.

187. Miller, R. A., Shi, Y., Lu, W., Pirman, D. A., Jatkar, A., Blatnik, M., Wu, H., Cárdenas, C., Wan, M., Foskett, J. K., Park, J. O., Zhang, Y., Holland, W. L., Rabinowitz, J. D., Birnbaum, M. J. (2018) Targeting hepatic glutaminase activity to ameliorate hyperglycemia. Nat. Med., 24: 518-524.

186. Lanaspa, M. A., Andres-Hernando, A., Orlicky, D. J., Cicerchi, C., Jang, C., Li, N., Milagres, T., Kuwabara, M., Wempe, M. F., Rabinowitz, J. D., Johnson, R. J., Tolan, D. R. (2018) Ketohexokinase C blockade ameliorates fructose-induced metabolic dysfunction in fructose-sesitive mice. J. Clin. Invest., 128: 2226-2238.

185. Gibney, P. A., Schieler, A., Chen, J. C., Bacha-Hummel, J. M., Botstein, M., Volpe, M. Silverman, S. J., Xu, Y., Bennett, B. D., Rabinowitz, J. D., Botstein, D. (2018) Common and divergent features of galactose-1-phosphate and fructose-1-phosphate toxicity in yeast. Mol. Biol. Cell, 29: 897-910.

184. McKee, S. E., Zhang, S., Chen, L., Rabinowitz, J. D., Reyes, T. (2018) Perinatal high fat diet and early life methyl donor supplementation alter one carbon metabolism and DNA methylation in the brain. J. Neurochem., 145: 362-373.

183. Jang, C. J., Hui, S., Lu, W., Cowan, A. J., Morscher, R. J., Lee, G., Liu, W., Tesz, G. J., Birnbaum, M. J., Rabinowitz, J. D. (2018) The small intestine converts dietary fructose into glucose and organic acids. Cell Metab., 27: 351-361.

182. Morscher, R. J., Ducker, G. S., Li, S. H., Mayer, J. A., Gitai, Z., Sperl, W., Rabinowitz, J. D. (2018) Mitochondrial translation requires folate-dependent tRNA methylation. Nature, 554: 128-132.

181. Pavlova, N. N., Hui, S., Ghergurovich, J. M., Fan, J., Intlekofer, A. M., White, R. M., Rabinowitz, J. D., Thompson, C. B., Zhang, J. (2018) As extracellular glutamine levels decline, asparagine becomes an essential amino acid. Cell Metab., 27: 428-438.e5.

180. Lin, K. C., Torga, G., Wu, A., Rabinowitz, J. D., Murray, W. J., Sturm, J. C., Pienta, K. J., Austin R. (2017) Epithelial and mesenchymal prostate cancer cell population dynamics on a complex drug landscape. Converg. Sci. Phys. Oncol., 3: pii: 045001.

179. Rebecca, V. W., Nicastri, M. C., McLaughlin, N., Fennelly, C., McAfee, Q., Ronghe, A., Nofal, M., Lim, C. Y., Witze, E., Chude, C. I., Zhang, G., Alicea, G. M., Piao, S., Murugan, S., Ojha, R., Levi, S. M., Wei, Z., Barber-Rotenberg, J. S., Murphy, M. E., Mills, G. B., Lu, Y., Rabinowitz, J., Marmorstein, R., Liu, Q., Liu, S., Xu, X., Herlyn, M., Zoncu, R., Brady, D. C., Speicher, D. W., Winkler, J. D., Amaravadi, R. K. (2017) A unified approach to targeting the lysosome's degradative and growth signaling roles. Cancer Discov., 7: 1266-1283.

178. Lee, G., Zheng, Y., Cho, S., Jang, C.,England, C., Dempsey, J. M., Yu, Y., Liu, X., He, L., Cavaliere, P. M., Chavez, A., Zhang, E., Isik, M., Couvillon, A., Dephoure, N. E., Blackwell, T. K., Yu, J. J., Rabinowitz, J. D., Cantley, L. C., Blenis, J. (2017) Post-transcriptional regulation of de novo lipogenesis by mTORC1-S6K1-SRPK2 signaling. Cell, 171: 1545-1558.

177. Ducker, G. S., Ghergurovich, J. M., Mainolfi, N., Suri, V., Jeong, S. K., Hsin-Jung, Li S., Friedman, A., Manfredi, M. G., Gitai, Z., Kim, H., Rabinowitz, J. D. (2017) Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc. Natl. Acad. Sci. USA, 114: 11404-11409.

176. Hui, S., Ghergurovich, J. M., Morscher, R. J., Jang, C., Teng, X., Lu, W., Esparza, L. A., Reya, T., Le, Z., Yanxiang Guo, J., White, E., Rabinowitz, J. D. (2017) Glucose feeds the TCA cycle via circulating lactate. Nature, 551: 115-118.

175. Wooldridge, A. L., Bischof, R. J., Liu, H., Heinemann, G. K., Hunter, D. S., Giles, L. C., Simmons, R. A., Lien, Y. C., Rabinowitz, J. D., Kind, K. L., Owens, J. A., Clifton, V. L., Gatford, J. L. (2017) Late gestation maternal dietary methyl donor and cofactor supplementation in sheep partially reverses protection against allergic sensitization by IUGR. Am. J. Physiol. Regul. Integr. Comp. Physiol, 314: R22-R33.

174.Liu, L. X., Rowe, G. C., Yang, S., Li. J., Damilano, F., Chan, M. C., Lu, W., Jang, C., Wada, S., Morley, M., Hesse, M., Fleischmann, B. K., Rabinowitz, J., Das, S., Rosenzweig, A., Arany, Z. (2017) PDK4 inhibits cardiac pyruvate oxidation in late pregnancy. Cir. Res., 121: 1370-1378.

173. Kim, H. I., Raffler, J., Lu, W., Lee, J. J., Abbey, D., Saleheen, D., Rabinowitz, J. D., Bennett, M. J., Hand, N. J., Brown, C., Rader, D. J. (2017) Fine mapping and functional analysis reveal a role of SLC22A1 in acylcarnitine transport. Am. J. Hum. Genet., 101: 489-502.

172. Nofal, M., Zhang, K., Han, S., Rabinowitz, J. D. (2017) mTOR inhibition restores amino acid balance in cells dependent on catabolism of extracellular protein. Mol. Cell, 67: 936-945.e5.

171. Zhang, Z., Chen, L., Liu, L., Su, X., Rabinowitz, J. D. (2017) Chemical basis for deuterium labeling of fat and NADPH. J Am Chem Soc, 139: 14368-14371.

170. Zhang, Y., Kurupati, R., Liu, L., Zhou, X. Y., Zhang, G., Hudaihed, A., Filisio, F., Giles-Davis, W., Xu, X., Karakousis, G. C., Schuchter, L. M., Xu, W., Amaravadi, R., Xiao, M., Sadek, N., Krepler, C., Herlyn, M., Freeman, G. J., Rabinowitz, J. D., Ertl, H. C. J. (2017) Enhancing CD8+ T cell fatty acid catabolism within a metabolically challenging tumor microenvironment increases the efficacy of melanoma immunotherapy. Cancer Cell, 32: 377-391.e9.

169. Chen, L., Ducker, G. S., Lu, W., Teng, X., Rabinowitz, J. D. (2017) An LC-MS chemical derivatization method for the measurement of five different one-carbon states of cellular tetrahydrofolate. Anal. Bioanal. Chem., 409: 5955-5964.

168. Oslund, R. C., Su, X., Haugbro, M., Kee, J. M., Esposito, M., David, Y., Wang, B., Ge, E., Perlman, D. H., Kang, Y., Muir, T. W., Rabinowitz, J. D. (2017) Bisphosphoglycerate mutase controls serine pathway flux via 3-phosphoglycerate. Nat. Chem. Biol., 13: 1081-1087.

167. Song, Y., Marmion, R. A., Park, J. O., Biswas, D., Rabinowitz, J. D., Shvartsman, S. Y. (2017) Dynamic control of dNTP synthesis in early embryos. Dev. Cell., 42: 301-308.e3,

166. Lu, W., Su, X., Klein, M. S., Lewis, I. A., Fiehn, O., Rabinowitz, J. D. (2017) Metabolite measurement: Pitfalls to avoid and practices to follow. Annu. Rev. Biochem., 86: 277-304.

165. Rajeshkumar, N. V., Yabuuchi, S., De Oliveira, E., Kamphorst, J. J., Rabinowitz, J. D., Tejero, H., Al-Shahrour, F., Hidalgo, M., Maitra, A., Dang, C. V. (2017) Treatment of pancreatic cancer patient-derived xenograft panel with metabolic inhibitors reveals efficacy of phenformin. Clin. Cancer Res., 23: 5639-5647.

164. Gong, Y., Cao, R., Ding, G., Hong, S., Zhou, W., Lu, W., Damle, M., Fang, B., Wang, C. C., Qian, J., Lie, N., Lanzillotta, C., Rabinowitz, J. D., Sun, Z. (2017) Integrated omics approaches to characterize a nuclear receptor corepressor-associated histone deacetylase in mouse skeletal muscle. Mol. Cell Endocrinol., 471: 22-32.

163. Choi, J., Rajagopal, A. Xu, Y. F., Rabinowitz, J. D., O'Shea, E. K. (2017) A systematic genetic screen for genes involved in sensing inorganic phosphate availability in Saccharomyces cerevisiae. PLoS One, 12: e0176085.

162. Lu, W., Wang, L., Chen, L., Hui, S., Rabinowitz, J. D. (2017) Extraction and quantitation of NAD redox cofactors. Antioxid. Redox Signal, 28: 167-179.

161. Su, X., Lu, W., Rabinowitz, J. D. (2017) Metabolite spectral accuracy on orbitraps. Anal. Chem., 89: 5940-5948.

160. Davidson, S. M., Jonas, O., Keibler, M. A., Hou, H. W., Luengo, A., Mayers, J. R., Wyckoff, J., Del Rosario, A. M., Whitman, M., Chin, C. R., Condon, K. J., Lammers, A., Kellersberger, K. A., Stall, B. K., Stephanopoulos, G., Bar-Sagi, D., Han, J., Rabinowitz, J. D., Cima, M. J., Langer, R., Vander Heiden, M. G. (2016) Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors. Nat. Med., 23: 235-241.

159. Hong S., Zhou, W., Fang, B., Lu, W., Loro, E., Damle M., Ding, G., Jager, G., Zhang, S., Zhang, Y., Feng, D., Chu, Q., Dill, B. D., Molina, H., Khurana, T. S., Rabinowitz, J. D.,Lazar, M. A., Sun, Z. (2016) Dissociation of muscle insulin sensitivity from exercise endurance in mice by HDAC3 depletion. Nat. Med., 23: 223-234.

158. Papazyan, R., Sun, Z., Kim, Y. H., Titchenell,P. M., Hill, D. A., Lu, W., Damle, M., Wan, M., Zhang, Y., Briggs, E. R., Rabinowitz, J. D., Lazar, M. A. (2016) Physiological suppression of lipotoxic liver damage by complementary actions of HDAC3 and SCAP/SREBP. Cell Metab., 24: 863-874.

157. Hackett, S. R., Zanotelli, V. R., Xu, W., Goya, J., Park, J. O., Perlman, D. H., Gibney, P. A., Botstein, D., Storey, J. D., Rabinowitz, J. D. (2016) Systems-level analysis of mechanisms regulating yeast metabolic flux. Science, 354: aaf2786.

156. Ducker, G. S. and Rabinowitz, J. D. (2016) One-carbon metabolism in health and disease. Cell Metab., 25: 27-42..

155. Moloughney, J. G., Kim, P. K., Vega-Cotto, N. M., Wu, C. C., Zhang, S., Adlam, M., Lynch, T., Chou, P. C., Rabinowitz, J. D., Werlen, G., Jacinto, E. (2016) mTORC2 responds to glutamine catabolite levels to modulate the hexosamine biosynthesis enzyme GFAT1. Mol. Cell, 63: 811-26.

154. Guo, J. Y., Teng, X., Laddha, S. V., Ma, S., Van Nostrand, S. C., Yang, Y., Khor, S., Chan, C. S., Rabinowitz, J. D., White, E. (2016) Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells. Genes Dev., 30: 1704-17.

153. Frederick, D. W., Loro, E., Liu, L., Davila, A. Jr.,Chellappa, K., Silverman, I. M., Quinn, W. J. 3rd, Gosai, S. J., Tichy, E. D., Davis, J. G., Mourkioti, F., Gregory, B. D., Dellinger, R. W., Redpath, P., Migaud, M. E., Nakamaru-Ogiso, E., Rabinowitz, J. D., Khurana, T. S., Baur, J. A. (2016) Loss of NAD homeostasis leads to progressive and reversible degeneration of skeletal muscle. Cell Metab., 24: 269-82.

152. Ron-Harel, N., Santos, D., Ghergurovich, J. M., Sage, P. T., Reddy, A., Lovitch, S. B., Dephoure, N., Satterstrom, F. K., Sheffer, M., Spinelli, J. B., Gygi, S., Rabinowitz, J. D., Sharpe, A. H., Haigis, M. C. (2016) Mitochondrial biogenesis and proteome remodeling promote one-carbon metabolism for T cell activation. Cell Metab. 24: 104-107.

151.Teng, X., Emmett, M. J., Lazar, M. A., Goldberg, E., Rabinowitz, J. D. (2016) Lactate dehydrogenase C produces S-2-Hydroxyglutarate in mouse testis. ACS Chem. Biol., 11: 2420-7.

150. Titchenell, P. M., Quinn, W. J., Lu, M., Chu, Q., Lu, W., Li, C., Chen, H., Monks, B, R., Chen, J., Rabinowitz, J. D., Birnbaum, M. J. (2016) Direct hepatocyte insulin signaling is required for lipogenesis but is dispensable for the suppression of glucose production. Cell Metab., 23: 1154-66.

149. Ducker, G. S., Chen, L., Morscher, R. J., Ghergurovich, J. M., Esposito, M., Teng, X., Kang, Y., Rabinowitz, J. D. (2016) Reversal of cytosolic one-carbon flux compensates for loss of the mitochondrial folate pathway. Cell Metab., 23: 1140-53.

148. Park, J. O., Rubin, S. A., Xu, Y. F., Amador-Noguez, D., Fan, J., Shlomi, T., Rabinowitz, J. D. (2016) Metabolite concentrations, fluxes and free energies imply efficient enzyme usage. Nat. Chem. Biol., 12: 482-9.

147. Bren, A., Park, J. O., Towbin, B. D., Dekel, E., Rabinowitz, J. D., Alon, U. (2016) Glucose becomes one of the worst carbon sources for E. coli on poor nitrogen sources due to suboptimal levels of cAMP. Sci. Rep., 6: 24834.

146. Rabinowitz, J. D., Coller, H. A. (2016) Partners in the Warburg effect. Elife, 5: e15938.

145. Liu, L., Shah, S., Fan, J., Park, J. O., Wellen, K. E., Rabinowitz, J. D. (2016) Malic enzyme tracers reveal hypoxia-induced switch in adipocyte NADPH pathway usage. Nat. Chem. Biol., 12: 345-52.

144. Koivunen, P., Fell, S. M., Lu, W., Rabinowitz, J. D., Kung, A. L., Schlisio, S. (2016) The 2-oxoglutarate analog 3-oxoglutarate decreases normoxic hypoxia-inducible factor 1α in cancer cells, induces cell death, and reduces tumor xenograft growth. Hypoxia, 4: 15-27.

143. Jang, C., Oh, S. F., Wada, S., Rowe, G. C., Liu, L., Chan, M. C., Rhee, J., Hoshino, A., Kim, B., Ibrahim, A., Baca, L. G., Kim, E., Ghosh, C. C., Parikh, S. M., Jiang, A., Chu, Q., Forman, D. E., Lecker, S. H., Krishnaiah, S., Rabinowitz, J. D., Weljie, A. M., Baur, J. A., Kasper, D. L., Arany, Z. (2016) A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance. Nat. Med., 22: 421-6.

142. Zong, W. X., Rabinowitz, J. D., White, E. (2016) Mitochondria and cancer. Mol. Cell, 61: 667-76.

141. Su, X., Wellen, K. E., Rabinowitz, J. D. (2016) Metabolic control of methylation and acetylation. Curr. Opin. Chem. Biol., 30: 52-60.

140. Bott, A. J., Peng, I. C., Fan, Y., Faubert, B., Zhao, L., Li, J., Neidler, S., Sun, Y., Jaber, N., Krokowski, D., Lu, W., Pan, J. A., Powers, S., Rabinowitz, J., Hatzoglou, M., Murphy, D. J., Jones, R., Wu, S., Girnun, G., Zong, W. X. (2015) Oncogenic Myc induces expression of glutamine synthetase through promoter demethylation. Cell Metab., 22: 1068-77.

139. Mok, W. W., Park, J. O., Rabinowitz, J. D., Brynildsen, M. P. (2015) RNA futile cycling in model persisters derived from MazF accumulation. MBio, 6: e01588-15.

138. Rajeshkumar, N. V., Dutta, P., Yabuuchi, S., de Wilde, R. F., Matrinez, G. V., Le, A., Kamphorst, J. J., Rabinowitz, J. D., Jain, S. K., Hidalgo, M., Dang, C. V., Gillies, R. J., Maitra, A. (2015) Therapeutic targeting of the Warburg effect in pancreatic cancer relies on an absence of p53 function. Cancer Res., 75: 3355-64.

137. Gibney, P. A., Schieler, A., Chen, J. C., Rabinowitz, J. D., Botstein, D. (2015) Characterizing the in vivo role of trehalose in Saccharomyces cerevisiae using the AGT1 transporter. Proc. Natl. Acad. Sci. USA, 112: 6116-21.

136. Purdy, J. G., Shenk, T., Rabinowitz, J. D. (2015) Fatty Acid elongase 7 catalyzes lipidome remodeling essential for human cytomegalovirus replication. Cell Rep., 10: 1375-85.

135. Buescher, J. M., et. al. (2015) A roadmap for interpreting ¹³C metabolite labeling patterns from cells. Curr. Opin. Biotechnol., 34: 189-201.

134. Kamphorst, J. J., Nofal, M., Commisso, C., Hackett, S. R., Lu, W., Grabocka,E., Vander Heiden, M. G., Miller, G., Drebin, J. A., Bar-Sagi, D., Thompson, C. B., Rabinowitz, J. D. (2015) Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein. Cancer Res., 75: 544-53.

133. Ducker, G. S. and Rabinowitz, J. D. (2015) ZMP: A master regulator of one-carbon metabolism. Mol. Cell, 57: 203-4.

132. Xu, Y. F., Lu, W., Rabinowitz, J. D. (2015) Avoiding misannotation of in-source fragmentation products as cellular metabolites in liquid chromatography-mass spectrometry-based metabolomes. Anal. Chem., 87: 2273-81.

131. Aristilde, L., Lewis, I. A., Park, J. O., Rabinowitz, J. D. (2014) Hierarchy in pentose sugar metabolism in clostridium acetobutylicum. Appl. Environ. Microbiol., 81: 1452-62.

130. Hwang, J., Purdy, J. G., Wu, K., Rabinowitz, J. D., Shenk, T. (2014) Estrogen-related receptor α is required for efficient human cytomegalovirus replication. Proc. Natl. Acad. Sci. USA, 111: E5706-17.

129. Kamphorst, J. J., Chung, M. K., Fan, J., Rabinowitz, J. D. (2014) Quantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate. Cancer & Metabolism, 2: 23.

128. Fan, J., Teng, X., Liu, L., Mattaini, K. R., Looper, R. E., Vander Heiden, M. G., Rabinowitz, J. D. (2014) Human phosphoglycerate dehydrogenase produces the oncometabolite d-2-hydroxyglutarate. ACS Chem Biol., 10: 510-6.

127. Castellana, M., Wilson, M. Z., Xu, Y., Joshi, P., Cristea, I. M., Rabinowitz, J. D., Gitai, Z., Wingreen, W. S. (2014) Enzyme clustering accelerates processing of intermediates through metabolic channeling. Nat. Biotechnol., 32: 1011-8.

126. Stincone, A., Prigione, A., Cramer, T., Wamelink, M. M., Campbell, K., Cheung, E., Olin-Sandoval, V., Gruening, N. M., Krueger, A., Tauqeer Alam, M., Keller, M. A., Breitenbach, M., Brindle, K. M., Rabinowitz, J. D., Raiser, M. (2014) The return of metabolism: biochemistry and physiology of the pentose phosphate pathway. Biol. Rev. Camb. Philos. Soc., 90: 927-63.

125. Zhang, J., Fan, J., Venneti, S., Cross, J. R., Takagi, T., Bhinder, B., Djaballah, H., Kanai, M., Cheng, E. H., Judkins, A. R., Pawel, B., Baggs, J., Cherry, S., Rabinowitz, J. D., Thompson, C. B. (2014) Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion. Mol. Cell, 56: 205-18.

124. Ye, J., Fan, J., Venneti, S., Wan, Y. W., Pawel, B. R., Zhang, J., Finley, L. W., Lu, C., Linsten, T., Cross, J., Qing, G., Liu, Z., Simon, M. C., Rabinowitz, J. D., Thompson, C. (2014) Serine catabolism regulates mitochondrial redox control during hypoxia. Cancer Discov., 4: 1406-17.

123. Mathew, R., Khor, S., Hackett, S. R., Rabinowitz, J. D., Perlman, D. H., White, E. (2014) Functional role of autophagy-mediated proteome remodeling in cell survival signaling and innate immunity. Mol. Cell, 55: 916-30.

122. Karsli-Uzunbas, G., Guo, J. Y., Price, S. M., Teng, X., Laddha, S. V., Khor, S., Kalaany, N. Y., Jacks, T., Chan, C. S., Rabinowitz, J. D., White, E. (2014) Autophagy is required for glucose homeostasis and lung tumor maintenance. Cancer Discov., 4: 914-27.

121. Fan, J., Ye, J., Kamphorst, J. J., Shlomi, T., Thompson, C. B., Rabinowitz, J. D. (2014) Quantitative flux analysis reveals folate-dependent NADPH production. Nature, 510: 298-302.

120. Breunig, J. S., Hackett, S. R., Rabinowitz, J. D., Krugkyak, L. (2014) Genetic basis of metabolome variation in yeast. PLoS Genet., 10: e1004142.

119. Shlomi, T., Fan, J., Tang, B., Kruger, W. D., Rabinowitz, J. D. (2014) Quantitation of cellular metabolic fluxes in methionine. Anal. Chem., 86: 1583-91.

118. Kliegman, J. I., Fiedler, D., Ryan, C. J., Xu, Y. F., Su, X. Y., Thomas, D., Caccese, M. C., Cheng, A., Shales, M., Rabinowitz, J. D., Krogan, N. J., Shokat, K. M. (2013) Chemical genetics of rapamycin-insensitive TORC2 in s. cerevisiae. Cell Rep., 5: 1725-36.

117. Fan, J., Kamphorst, J. J., Mathew, R., Chung, M. K., White, E., Shlomi, T., Rabinowitz, J. D. (2013) Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia. Mol. Syst. Biol., 9: 712.

116. Grady, S. L., Purdy, J. G., Rabinowitz, J. D., Shenk, T. (2013) Argininosuccinate synthetase 1 depletion produces a metabolic state conducive to herpes simplex virus 1 infection. Proc. Natl. Acad. Sci. USA, 110: E5006-15.

115. Tchigvintsev, A., Tchigvintsev, D., Flick, R., Popovic, A., Dong, A., Xu, X., Brown, G., Lu, W., Wu, H., Dombrowski, L., Joo, J. C., Beloglazova, N., Min, J., Savchenko, A., Caudy, A. A., Rabinowitz, J. D., Murin, A. G., Yakunin, A. F. (2013) Biochemical and structural studies of conserved maf proteins revealed nucleotide pyrophosphatases with a preference for modified nucleotides.Chem. Biol., 20: 1386-98.

114. Tepper, N., Noor, E., Amador-Noguez, D., Haraldsdóttir, H. S., Milo, R., Rabinowitz, J.,Liebermeister, W., Shlomi, T. (2013) Steady-state metabolite concentrations reflect a balance between maximizing enzyme efficiency and minimizing total metabolite load. PLoS One, 8: e75370.

113. Fan, J., Kamphorst, J. J., Rabinowitz, J. D., Shlomi, T. (2013) Fatty acid labeling from glutamine in hypoxia can be explained by isotope exchange without net reductive IDH flux. J. Biol. Chem., 288: 31363-9.

112. Rabinowitz, J. D. and Silhavy, T. J. (2013) Systems biology: metabolite turns master regulator. Nature, 500: 283-4.

111. Reaves, M.L., Young, B. D., Hosios, A. M., Xu, Y. F., Rabinowitz, J. D. (2013) Pyrimidine homeostasis is accomplished by directed overflow metabolism. Nature, 500(7461): 237-41.

110. Guo, L. Y., Karsli-Uzunbas, G., Mathew, R., Aisner, S. C., Kamphorst, J.J., Strohecker, A. M., Chen, G., Price, S., Lu, W., Teng, X., Snyder, E., Santanam, U., Dipaola, R. S., Jacks, T., Rabinowitz, J. D., White, E. (2013) Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis. Genes Dev., 27: 1447-61.

109. Koyuncu, E., Purdy, J. G., Rabinowitz, J. D., Shenk, T. (2013) Saturated very long fatty acids are required for the production of infectious human cytomegalovirus progeny. PLoS Pathog., 9: e1003333.

108. Kamphorst, J. J., Cross, J. R., Fan, J., de Stanchina, E., Mathew, R., White, E. P., Thompson, C. B., Rabinowitz, J. D. (2013) Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids. Proc. Natl. Acad. Sci. USA, 110: 8882-7.

107. Xu, Y. F., Létisse, F., Absalan, F., Lu, W., Kuznetsova, E., Brown, G., Caudy, A. A., Yakunin, A. F., Broach, J. R., Rabinowitz, J. D. (2013) Nucleotide degradation and ribose salvage in yeast. Mol. Syst. Biol., 9: 665.

106. Commiso, C., Davidson, S. M., Soydaner-Azeloglu, R. g., Parker, S. J., Kamphorst, J. J., Hackett, S., Grabocka, E., Nofal, M., Drebin, J. A., Thompson, C. B., Rabinowitz, J. D., Metallo, C. M. (2013) Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells. Nature, 497: 633-7.

105. Shlomi T. and Rabinowitz, J. D. (2013) Metabolism: Cancer mistunes methylation. Nat. Chem. Biol., 9: 293-4.

104. Xu, Y. F., Zhao, X., Glass, D. S., Absalan, F., Perlman, D. H., Broach, J. R., Rabinowitz, J. D. (2012) Regulation of yeast pyruvate kinase by ultrasensitive allostery independent of phosphorylation. Mol. Cell, 48: 52-62.

103. Bray, K., Mathew, R., Lau, A., Kamphorst, J. J., Fan, J., Chen, J., Chen, H. Y., Ghavami, A., Stein, M., Dipaola, R. S., Zhang, D., Rabinowitz, J. D., White, E. (2012) Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition. PLoS One, 7: e41831.

102. Reaves, M. L., Sinha, S., Rabinowitz, J. D., Kruglyak, L., Redfield, R. J. (2012) Absence of detectable arsenate in DNA from arsenate-grown GFAJ-1 cells. Science, 337: 470-3.

101. Grady, S. L., Hwang, J., Vastag, L., Rabinowitz, J. D., Shenk, T. (2012) Herpes simplex virus type 1 infection activates poly (ADP-ribose) polymerase and triggers the degradation of poly (ADP-ribose) glycohydrolase. J. Virol., 86: 8259-68.

100. Rabinowitz, J. D. and Vastag, L. (2012) Teaching the design principles of metabolism. Nat. Chem.Biol., 8:497-501.

99. Xu, Y., Amador-Noguez, D., Reaves, M. L., Feng, X. J., Rabinowitz, J. D. (2012) Ultrasensitive regulation of anapleurosis via allosteric activation of PEP carboxylase. Nat. Chem. Biol., 8: 562-68.

98. Ye, J., Mancuso, A., Tong, X., Ward, P. S., Fan, J., Rabinowitz, J. D., Thompson, C. B. (2012). Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation. Proc. Natl. Acad. Sci. USA, 109: 6904-09.

97. Peterson, C. N., Levchenko, I., Rabinowitz, J. D., Baker, T. A., Silhavy, T. J. (2012). RpoS proteolysis is controlled directly by ATP levels in Escherichia coli. Genes Dev., 26: 548-53.

96. Clasquin, M. F, Melamud, E., Rabinowitz, J. D. (2012). LC-MS Data Processing with MAVEN: A Metabolomic Analysis and Visualization Engine. Curr. Protoc. Bioinformatics, 14: Unit14.11.

95. Terry, L. J., Vastag, L., Rabinowitz, J. D., Shenk, T. (2012). Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection. Proc. Natl. Acad. Sci. USA, 109:3071-6.

94. Rabinowitz, J. D., Purdy, J. G., Vastag, L., Shenk, T., Koyuncu, E. (2011).Metabolomics in drug target discovery. Cold Spring Harb. Symp. Quant. Biol., 76: 235-46.

93. Kamphorst, J. J., Fan, J., Lu, W., White, E., Rabinowitz, J. D. (2011). Liquid chromatography-high resolution mass spectrometry analysis of fatty acid metabolism. Anal. Chem., 83: 9114-22.

92. Doucette, C. D., Schwab, D. J., Wingreen, N. S., Rabinowitz, J. D. (2011). α-Ketoglutarate coordinates carbon and nitrogen utilization via enzyme I inhibition. Nat. Chem. Biol., 7: 894-901.

91. Amador-Noguez, D. Brasg, I. A., Feng, X. J., Roquet, N., Rabinowitz, J. D. (2011). Metabolome remodeling during the acidogenic-solventogenic transition in Clostridium acetobutylicum. Appl. Environ. Microbiol., 77: 7984-97.

90. Strelko, J. L., Lu, W., Dufort, F. J., Seyfried, T. N., Chiles, T. C., Rabinowitz, J. D., Roberts, M. F. (2011). Itaconic acid is a mammalian metabolite induced during macrophage activation. J. Am. Chem. Soc., 133: 16386-9.

89. Vastag, L., Koyuncu, E., Grady, S. L., Shenk, T. E., Rabinowitz, J. D. (2011). Divergent effects of human cytomegalovirus and herpes simplex virus-1 on cellular metabolism. PLoS Pathog., 7: e1002124.

88. Liu, S. T. H., Sharon-Frilling, R., Ivanova, P., Milne, S. B., Myers, D. S., Rabinowitz, J. D., Brown, H. A., Shenk, T. (2011). Synaptic vesicle-like lipidome of human cytomegalovirus virions reveals a role for SNARE machinery in virion egress. PNAS, 108: 12869-74.

87. Petti, A. A., Crutchfield, C. A., Rabinowitz, J. D., Botstein, D. (2011). Survival of starving yeast is correlated with oxidative stress response and nonrespiratory mitochondrial function. Proc. Natl. Acad. Sci. USA, 108: E1089-98.

86. Clasquin, M. F., Melamud, E., Singer, A., Gooding, J. R., Xu, X., Dong, A., Cui, H., Campagna, S. R., Savchenko, A., Yakunin, A. F., Rabinowitz, J. D., Caudy, A. A. (2011). Riboneogenesis in yeast. Cell, 145: 969-980.

85. Reaves, M. L. and Rabinowitz, J. D. (2011). Characteristic phenotypes associated with ptsN-null mutants in Escherichia coli K-12 are absent in strains with functional ilvG. J. Bacteriol., 193: 4676-81.

84. Guo, J. X., Chen, H.Y., Mathew, R., Fan, J., Strohecker, A, M., Karsli-Uzunbas, G., Kamphorst, J. J., Chen, G., Lemmons, J. M. S., Karantza, V., Coller, H. A., DiPaola, R. S., Gelinase, C., Rabinowitz, J. D., White, E. (2011). Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes & Dev., 25: 460-470.

83. Klosinska, M. M., Crutchfield, C., Bradley, P. J., Rabinowitz, J. D., Broach, J. R. (2011). Yeast cells can access distinct quiescent states. Genes Dev., 25: 336-49.

82. Vastag, L., Jorgensen, P., Peshkin, L., Rabinowitz, J. D., Kirschner, M. W. (2011). Remodeling of the metabolome during early frog development. PLoS ONE, 6: e16881.

81. Hart, Y., Madar, D., Yuan, J., Bren, A., Mayo, A. E., Rabinowitz, J. D., Alon, U. (2011) Robust control of nitrogen assimilation by a bifunctional enzyme in E. coli. Mol. Cell, 41: 117-127.

80. Merritt, J. H., Ha, D.G., Cowles, K. N., Lu, W., Morales, D. K., Rabinowitz, J., Gitai, Z., O’Toole, G. A. (2010). Specific control of Pseudomonas aeruginosa surface-associated behaviors by two c-di-GMP diguanylate cyclases. mBio, 1: pii. e00183-10.

79. Wellen, K. E., Lu, Lu, C., Mancuso, A., Lemons, J. M., Ryczko, M., Dennis, J. W., Rabinowitz, J. D., Coller, H. A., Thompson, C. B. (2010). The hexosamine biosynthetic pathwaycouples growth factor -induced glutamine uptake to glucose metabolism. Genes Dev., 24: 2784-2799.

78. Rabinowitz, J. D. and White, E. (2010). Autophagy and metabolism. Science, 330: 1344-8.

77. Melamud, E., Vastag, L., Rabinowitz, J. D. (2010) Metabolomic analysis and visualization engine for LC-MS data. Anal. Chem., 82: 9818-9826.

76. Seltzer, M. J., Bennett, B. D., Joshi, A. D., Gao, P., Thomas, A. G., Ferraris, D. V., Tsukamoto, T., Rojas, C. J., Slusher, B. S., Rabinowitz, J. D., Dang, C. V., Riggins, G. L. (2010). Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1. Cancer Res., 70: 8981-7.

75. Reaves, M. L. and Rabinowitz, J. D. (2010) Metabolomics in systems microbiology. Curr. Opin. Biotechnol., 22: 17-25.

74. Lemons, J. M. S., Feng, X. J., Bennett, B. D., Legesse-Miller, A., Johnson, E. L., Raitman, I., Pollina, E. A., Rabitz, H. A., Rabinowitz, J. D., Coller, H. A. (2010). Quiescent fibroblasts exhibit high metabolic activity. PLoS Biol., 8: e1000514.

73. Vander Heiden, M. G., Locasale, J. W., Swanson, K.D., Sharfi, H., Heffron, G.J., Amador-Noguez, D., Christofk, H. R., Wagner, G., Rabinowitz, J.D., Asara, J.M., Cantley, L.C. (2010) Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells. Science, 329: 1492-1499.

72. Amador-Noguez, D., Feng, X. F., Fan, J.,Roquet, N., Rabitz, H., Rabinowitz, J. D. (2010) Systems-level Metabolic Flux Profiling Elucidates a Complete, Bifurcated Tricarboxylic Acid Cycle in Clostridium acetobutylicum. J. Bacteriol., 192: 4452-4461.

71. Kwon., Y. K., Higgins, M. B., Rabinowitz, J. D. (2010) Antifolate-induced Depletion of Intracellular Glycine and Purines Inhibits Thymineless Death in E. coli. ACS Chem. Biol., 5: 787-795.

70. Goyal, S., Yuan, J., Chen, T., Rabinowitz, J. D., Wingreen, N. S. (2010) Achieving Optimal Growth through Product Feedback Inhibition in Metabolism. PLoS Comput. Biol., 6: e1000802.

69. Goodarzi, H., Bennett, B. D., Amini, S., Reaves, M. L., Hottes, A. K., Rabinowitz, J. D., Tavazoie, S. (2010) Regulatory and Metabolic Rewiring during Laboratory Evolution of Ethanol Tolerance in E. coli. Mol. Syst. Biol., 6: 378.

68. Crutchfield, C., Lu, W., Melamud, E., Rabinowitz, J. D. (2010) Mass Spectrometry-Based Metabolomics of Yeast. Methods Enzymol. 470: 393-426.

67. Kuchma, S. L., Ballok, A. E., Merritt, J. H., Hammond, J. H., Lu, W., Rabinowitz, J. D., O'Toole, G. A. (2010). Cyclic-di-GMP-Mediated Repression of Swarming Motility by Pseudomonas aeruginosa: The pilY1 Gene and its Impact on Surface-Associated Behaviors. J. Bacteriol., 192: 2950-64.

66. Lu, W., Clasquin, M. F., Melamud, E., Amador-Noguez, D., Caudy, A. A., Rabinowitz, J. D. (2010) Metabolomic analysis via reversed-phase ion-pairing liquid chromatography coupled to a stand alone orbitrap mass spectrometer. Anal. Chem., 82: 3212-3221.

65. Monds, R. D., Newell,, P. D., Wagner, J. C., Schwartzman, J. A., Lu, W., Rabinowitz, J. D., O'Toole, G. A. (2010). Di-adenosine tetraphosphate (Ap4A) metabolism impacts biofilm formation by Pseudomonas fluorescens via modulation of c-di-GMP-dependent pathways. J. Bacteriol., 192: 3011-23.

64. Ward, P. S., Patel, J., Wise, D. R., Abdel-Wahab, O., Bennett, B. D., Coller, H. A., Cross, J. R., Fantin, V. R., Hedvat, C. V., Perl, A. E., Rabinowitz, J. D., Carroll, M., Su, S. M., Sharp, K. A., Levine, T. L., Thompson, C. B. (2010). The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Cancer Cell, 17: 215-6.

63. Lu., X., Bennett, B., Mu, E., Rabinowitz, J., Kang, Y. (2010). Metabolomic changes accompanying transformation and acquisition of metastatic potential in a syngeneic mouse mammary tumor model. J. Biol. Chem., 285: 9319-21.

62. DiMaggio, P. A., McAllister, S. R., Floudas, C. A., Feng, X. J., Rabinowitz, J. D., Rabitz, H. A. (2010). A network flow model for biclustering via optimal re-ordering of data matrices. J. Glob. Optim., 47: 343-354.

61. DiMaggio, P. A., McAllister, S. R., Floudas, C. A., Feng, X. J., Li, G., Rabinowitz, J. D., Rabitz, H. A. (2010). Enhancing molecular discovery using descriptor-free rearrangement clustering techniques for sparse data sets. AIChE Journal, 56: 405-418.

60. Boer, V. M., Crutchfield, C. A., Bradley, P. H., Botstein, D., Rabinowitz, J. D. (2010). Growth-limiting intracellular metabolites in yeast growing under diverse nutrient limitations. Mol. Biol. Cell, 21: 198-211.

59. Dang, L., White, D.W., Gross, S., Bennett, B.D., Bittinger, M.A., Driggers, E.M., Fantin, V.R., Jang, H.G., Jin, S., Keenan, M.C., Marks, M., Prins, R.M., Ward, P.S., Yen, K.E., Liau, L.M., Rabinowitz, J.D., Cantley, L.C., Thompson, C.B., Vander Heiden, M.G., Su, S.M. (2009). Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature, 462: 739-44.

58. Kelly, R. C., Bolitho, M. E., Higgins, D. A., Lu, W., Ng, W. L., Jeffrey, P. D., Rabinowitz, J. D., Semmelhack, M. F., Hughson, F. M., Bassler, B. L. (2009) The Vibrio cholerae quorum-sensing autoinducer CAI-1: analysis of the biosynthetic enzyme CqsA. Nat. Chem. Biol., 5: 891-5.

57. Yuan, J., Doucette, C., Fowler, W. U., Feng, X. J., Piazza, M., Rabitz, H. A., Wingreen, N. S., Rabinowitz, J. D. (2009). Metabolomics-driven quantitative analysis of ammonia assimilation in E. coli. Mol. Syst. Biol., 5: 302.

56. Bennett, B. D., Kimball, E. H., Gao, M., Osterhout, R., Van Dien, S. J., Rabinowitz, J. D. (2009). Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli. Nat. Chem. Biol., 5: 593-9.

55. Olszewski, K. L., Morrisey, J. M., Wilinski, D., Burns, J. M., Vaidya, A. B., Rabinowitz, J. D., Llinás, M. (2009). Host parasite interactions revealed by Plasmodium falciparum metabolomics. Cell Host Microbe, 5: 191-9.

54. Shinar, G., Rabinowitz, J. D., Alon, U. (2009). Robustness in glyoxylate bypass regulation. PLoS Comp. Biol., 5: e1000297.

53. Bradley, P. H., Brauer, M. J., Rabinowitz, J. D., Troyanskaya, O. (2009). Coordinated concentration changes of transcript and metabolites in Saccharomyces cerevisiae . PLoS Comp. Biol., 5: e1000270.

52. DiMaggio, P. A., McAllister, S. R., Floudas, C. A., Feng, X. J., Rabinowitz, J. D., Rabitz, H. A. (2008). Biclustering via optimal re-ordering of data matrices in systems biology: Novel rigorous methods and comparative studies. BMC Bioinformatics, 9: 458.

51. McAllister, S. R., Feng, X. J., Dimaggio, P. A. Jr., Floudas, C. A., Rabinowitz, J. D., Rabitz, H. (2008). Descriptor-free molecular discovery in large libraries by adaptive substituent reordering. Bioorg. Med. Chem. Lett., 18: 5967-5970.

50. Munger, J., Bennett, B. D., Parikh, A., Feng, X. J., McArdle, J., Rabitz, H. A., Shenk, T., Rabinowitz, J. D. (2008). Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for anti-viral therapy. Nat. Biotechnol., 26: 1179-1186.

49. Kwon, Y. K., Lu, W., Melamud, E., Khanam, N., Bognar, A., Rabinowitz, J. D. (2008). A domino effect in antifolate drug action in Escherichia coli. Nat. Chem. Biol., 4: 602-608.

48. Yuan, J., Bennett, B. D., Rabinowitz, J. D. (2008).Kinetic flux profiling for quantitation of cellular metabolic fluxes. Nat. Protocols, 3: 1328-1340.

47. Bennett, B. D., Yuan, J., Kimball, E. H., Rabinowitz, J. D. (2008). Absolute quantitation of intracellular metabolite concentrations by an isotope ratio-based approach. Nat. Protocols, 3: 1299-1311.

46. Lu, W., Bennett, B. D., Rabinowitz, J. D. (2008). Analytical strategies for LC-MS-based targeted metabolomics . J. Chrom. B., 871: 236-242.

45. Waters, C. M., Lu, W., Rabinowitz, J. D., Bassler, B. L. (2008). Quorum sensing controls biofilm formation in Vibrio cholerae through modulation of cyclic di-GMP levels and repression of vpsT. J. Bacteriol., 190: 2527-2536.

44. Rabinowitz, J. D., Hsiao, J. J., Gryncel, K. R., Kantrowitz, E. R., Feng, X. J., Li, G., Rabitz, H. (2008). Dissecting enzyme regulation by multiple allosteric effectors: Nucleotide regulation of aspartate transcarbamoylase. Biochemistry, 47: 5881-5888.

43. Piazza, M., Feng, X. J., Rabinowitz, J. D., Rabitz, H. (2008). Diverse metabolic model parameters generate similar methionine cycle dynamics. J. Theor. Biol., 251: 628-639.

42. Cui, H., Hayashi, A., Sun, H. S., Belmares, M. P., Cobey, C., Phan, T., Schweizer, J., Salter, M. W., Wang, Y. T., Tasker, R. A., Garman, D., Rabinowitz, J., Lu, P. S., Tymianski, M. (2007). PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors. J. Neurosci., 27: 9901-9915.

41. Xavier, K. B., Miller, S. T., Lu, W., Kim, J. H., Rabinowitz, J., Pelczer, I., Semmelhack, M. F., Bassler, B. L. (2007). Phosphorylation and processing of the quorum-sensing molecule AI-2 in enteric bacteria. ACS Chem. Biol., 2: 128-136.

40. Yuan, J., Rabinowitz, J. D. (2007). Differentiating metabolites formed from de novo synthesis versus macromolecule decomposition. J. Am. Chem. Soc., 129: 9294-9295.

39. Rabinowitz, J. D., Kimball, E. (2007). Acidic acetonitrile for cellular metabolome extraction from Escherichia coli. Anal. Chem., 79: 6167-6173.

38. Lu, W., Kwon, Y. K., Rabinowitz, J.D. (2007). Isotope ratio-based profiling of microbial folates. J. Am. Soc. Mass Spectr., 18: 898-909.

37. Campagna, S. R., Rabinowitz, J. D. (2007). Metabolome quantitation mass spectrometry. G.I.T. Laboratory Journal, 7-8: 26-27.

36. Rabinowitz, J. D. (2007). Cellular metabolomics of Escherichia coli. Exp. Rev. Proteomics, 4: 187-198.

35. Avram, M. J., Henthorn, T. K., Spyker, D. A., Krejcie, T. C., Lloyd, P. M., Cassella, J. V., Rabinowitz, J. D. (2007). Recirculatory pharmacokinetic model of the uptake, distribution, and bioavailability of prochlorperazine administered as a thermally generated aerosol in a single breath to dogs. Drug. Metab. Dispos., 35: 262-267.

34. Bao, Q., Lu, W., Rabinowitz, J. D., Shi, Y. (2007). Calcium blocks formation of apoptosome by preventing nucleotide exchange in Apaf-1. Mol. Cell, 25: 181-192.

33. Myers, D. J., Timmons, R. D., Lu, A. T., Hale, R. L., Solas, D. W., Soni, P., Rabinowitz, J. D. (2007). Effect of film thickness on thermal aerosol generation. Pharm. Res., 24: 336-342.

32. Brauer, M. J., Yuan, J., Bennett, B. D., Lu, W., Kimball, E., Botstein, D., Rabinowitz, J. D. (2006). Conservation of the metabolomic response to starvation across two divergent microbes. Proc. Natl. Acad. Sci. USA, 103: 19302-19307.

31. Munger, J., Bajad, S. U., Coller, H. A., Shenk, T., Rabinowitz, J. D. (2006). Dynamics of the cellular metabolome during human cytomegalovirus infection. PLoS Pathogens, 2: 1165.

30. Hess, D. C., Lu, W., Rabinowitz, J. D., Botstein, D. (2006). Ammonium toxicity and potassium limitation in yeast. PLos Biology, 4: 2012-2023.

29. Kimball, E., Rabinowitz, J. D. (2006). Identifying decomposition products in extracts of cellular metabolites. Anal. Biochem., 358: 273-80.

28. Yuan, J., Fowler, W. U., Kimball, E., Lu, W., Rabinowitz, J. D. (2006). Kinetic flux profiling of nitrogen assimilation in Escherichia coli. Nat. Chem. Biol., 2: 529-530.

27. Bajad, S. U., Lu, W., Kimball, E. H., Yuan, J., Peterson, C., Rabinowitz, J. D. (2006). Separation and quantitation of water soluble cellular metabolites by hydrophilic interaction chromatography – tandem mass spectrometry. J. Chrom. A., 1125: 76-88.

26. Rabinowitz, J. D., Lloyd, P. M., Munzar, P., Myers, D. J., Cross, S., Damani, R., Quintana, R., Spyker, D. A., Soni, P., Cassella, J. V. (2006). Ultra-fast absorption of amorphous pure drug aerosols via deep lung inhalation. J. Pharm. Sci., 95: 2438-2451.

25. Lu, W., Kimball, E., Rabinowitz, J. D. (2006). A high-performance liquid chromatography-tandem mass spectrometry method for quantitation of nitrogen-containing intracellular metabolites. J. Am. Soc. Mass Spectr., 17: 37-50.

24. Rabinowitz, J. D., Wensley, M., Lloyd, P., Myers, D., Shen, W., Lu, A., Hodges, C., Hale, R., Mufson, D., Zaffaroni, A. (2004). Fast onset medications through thermally generated aerosols. J. Pharmacol. Exp. Ther., 309: 769-775.

23. Turner-Cobb J. M., Koopman, C., Rabinowitz, J. D., Terr, A. I., Sephton, S. E., Spiegel, D. (2004). The interaction of social network size and stressful life events predict delayed-type hypersensitivity among women with metastatic breast cancer. Int. J. Psychophysiol., 54: 241-249.

22. Hall, F. C., Rabinowitz, J. D., Busch, R., Visconti, K. C., Belmares, M., Patil, N. S., Cope, A. P., Patel, S., McConnell, H. M., Mellins, E. D., Sonderstrup, G. (2002). Relationship between kinetic stability and immunogenicity of HLA-DR4/peptide complexes. Eur. J. Immunol., 32: 662-670.

21. Patil, N. S., Pashine, A., Belmares, M. P., Liu, W., Kaneshiro, B., Rabinowitz, J., McConnell, H., Mellins, E. D. (2001). Rheumatoid arthritis (RA)-associated HLA-DR alleles form less stable complexes with class II-associated invariant chain peptide than non-RA-associated HLA-DR alleles. J. Immunol., 167: 7157-7168.

20. Belmares, M. P., Rabinowitz, J. D., Lui, W., Mellins, E. D., McConnell, H. M. (2000). pH stability of HLA-DR4 complexes with antigenic peptides. Biochemistry, 39: 14558-14566.

19. Kasson, P. M., Rabinowitz, J. D., Schmitt, L., Davis, M. M., McConnell, H. M. (2000). Kinetics of peptide binding to the class II MHC protein I-Ek. Biochemistry, 39: 1048-1058.

18. Rabinowitz, J. D., Vrljic, M., Kasson, P. M., Liang, M. N., Busch, R., Boniface, J. J., Davis, M. M., McConnell, H. M. (1998). Formation of a highly peptide-receptive state of class II MHC. Immunity, 9: 699-709.

17. Boniface, J. J., Rabinowitz, J. D., Wulfing, C., Hampl, J., Reich, Z., Altman, J. D., Kantor, R. M., Beeson, C., McConnell, H. M., Davis, M. M. (1998). Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands. Immunity, 9: 459-466.

16. Lee, C., Liang, M. N., Tate, K. M., Rabinowitz, J. D., Beeson, C., Jones, P. P., McConnell, H. M. (1998). Evidence that the autoimmune antigen myelin basic protein (MBP) Ac1-9 binds towards one end of the major histocompatibility complex (MHC) cleft. J. Exp. Med., 187: 1505-1516.

15. Rabinowitz, J. D., Vacchino, J. F., Beeson, C., McConnell, H. M. (1998). Potentiometric measurement of intracellular redox activity. J. Am. Chem. Soc., 120: 2464-2473.

14. Petros, W. P., Rabinowitz, J., Gibbs, J. P., Hall, I. H., Stuart, A. R., Peters, W. P. (1998).Effect of plasma TNF-α on filgrastim-stimulated hematopoiesis in mice and humans. Pharmacotherapy, 18: 816-823.

13. Rabinowitz, J. D., Liang, M. N., Tate K., Lee C., Beeson C., McConnell H. M. (1997). Specific T cell recognition of kinetic isomers in the binding of peptide to class II major histocompatibility complex. Proc. Natl. Acad. Sci. USA, 94: 8702-8707.

12. Rabinowitz, J. D., Rigler P., Carswell-Crumpton, C., Beeson, C., McConnell, H. M. (1997). Screening for novel drug effects with a microphysiometer: a potent effect of clofilium unrelated to potassium channel blockade. Life Sci., 61: PL87-PL94.

11. Elkordy, M., Crump, M., Vredenburgh, J. J., Petros, W. P., Hussein, A., Rubin, P., Ross, M., Gilbert, C., Modlin, C., Meisenberg, B., Coniglio, D., Rabinowitz, J., Laughlin, M., Kurtzberg, J., Peters, W. P. (1997). A phase I trial of recombinant human interleukin-1 beta (OCT-43) following high-dose chemotherapy and autologous bone marrow transplantation. Bone Marrow Transpl., 19: 315-322.

10. Petros, W. P., Rabinowitz, J., Stuart, A., Peters W. P. (1997). Clinical pharmacology of filgrastim following high-dose chemotherapy and autologous bone marrow transplantation. Clin. Cancer Res., 3: 705-711.

9. Wulfing, C., Rabinowitz, J. D., Beeson C., Sjaastad M. D., McConnell H. M., Davis M. M. (1997). Kinetics and extent of T cell activation as measured with the calcium signal. J. Exp. Med., 185: 1815-1825.

8. Rabinowitz, J. D., Beeson, C., Wulfing C., Tate K., Allen P. M., Davis M. M., McConnell, H. M. (1996). Altered T cell receptor ligands trigger a subset of early T cell signals. Immunity, 5: 125-135.

7. Rabinowitz, J. D., Beeson C., Lyons D. S., Davis M. M., McConnell, H. M. (1996). Kinetic discrimination in T-cell activation. Proc. Natl. Acad. Sci. USA, 93: 1401-1405.

6. Beeson, C., Rabinowitz, J., Tate, K., Gutgemann, I., Chien, Y. H., Jones, P. P., Davis, M. M., McConnell, H. M. (1996). Early biochemical signals arise from low affinity TCR-ligand reactions at the cell-cell interface. J. Exp. Med., 184: 777-782.

5. Petros, W. P., Rosner, G. L., Rabinowitz, J., Gilbert, C. J., Coniglio, D., Vredenburgh J. J., Ross, M., Peters, W. P. (1996). The pharmacologic effects of recombinant, human colony-stimulating factors and their modulation by theophylline. Pharmacotherapy, 16: 742-748.

4. Petros W. P., Rabinowitz, J., Stuart A. R., Gupton C., Alderman, E. M., Peters, W. P. (1994). Elevated endogenous serum macrophage colony-stimulating factor in the early stage of fungemia following bone marrow transplantation. Exp. Hematol., 22: 582-586.

3. Rabinowitz, J., Petros, W. P., Peters, W. P. (1994). Cytokine kinetics: Clinical pharmacology studies complementing recombinant growth factor trials. Cancer Bulletin, 46: 40-47.

2. Rabinowitz, J., Petros, W. P., Stuart, A. R., Peters, W. P. (1993). Characterization of endogenous cytokine concentrations after high-dose chemotherapy with autologous bone marrow support. Blood, 81: 2452-2459.

1. Petros W. P., Rabinowitz, J., Stuart, A. R., Gilbert, C. J., Kanakura, Y., Griffin, J. D., Peters, W. P. (1992). Disposition of recombinant human granulocyte-macrophage colony-stimulating factor in patients receiving high-dose chemotherapy and autologous bone marrow support. Blood, 80: 1135-1140.